CYCLOOXYGENASE-2 EXPRESSION IN COLORECTAL CANCER IN NORTH INDIA- A PILOT STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 43
Abstract
BACKGROUND The aim of the study is to evaluate cyclooxygenase -2 (COX-2) expression in cases of sporadic cancer cases of colorectum. COX-2 is an important enzyme involved in inflammation, so in future COX-2 inhibitor could be used in the treatment of chronic inflammation of these organs as well as malignancies. MATERIALS AND METHODS Total number of 29 cases of colorectal cancer were studied in a period of one year. In this study, COX-2 expression is assessed by immunohistochemistry. RESULTS In our study, 15 males and 14 females were affected constituting almost equal ratio. Most of the cancers were seen in sixth decade of life. The mean age in the colon cancer is 46 ± 3.08 years respectively. COX-2 expression is seen in 80% cases of colorectal cancer and approximately 87.5% positive cases had either moderate or strong staining. CONCLUSION Thus, our study concluded that COX-2 inhibitors can be effective in treatment of cases of colorectal cancer along with other drugs, because 70% of these malignancies express COX-2.
Authors and Affiliations
Arundhati Arundhati
Keywords
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- EP ID EP214511
- DOI 10.14260/Jemds/2017/726
- Views 94
- Downloads 0
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