Cymbopogon citratus Stapf (DC) Extract Ameliorates Atherogenic Cardiovascular Risk in Diabetes-Induced Dyslipidemia in Rats
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 28
Abstract
Aims: Diabetic dyslipidemia is a recognized risk factor for coronary heart disease (CHD). Plant medicinal agents such as Cymbopogon citratus (C. citratus) have shown potential as alternative therapies for reducing cardiovascular risk factors. The aim of this study was to investigate the effect of C. citratus leaf extract on the atherogenic index of plasma (AIP) in diabetic dyslipidemic rats (n=35). Materials and Methods: A C. citratus extract was prepared by ethanol extraction of leaf material. Rats were divided into seven groups (n=5) as follows: (a) Normal diet control, (b) Hyperlipidemic diet (HLD) control, (c) HLD + 65mg/kg streptozotocin (STZ) control (d) HLD + STZ + 250mg/kg C. citratus extract (CCE), (e) HLD + STZ + 500mg/kg CCE, (f) HLD + STZ + 1000mg/kg CCE, and (g) HLD + STZ + 5mg/kg atorvastatin + 600µg/g glibenclamide. Animals were treated with HLD for 14 days and then injected intraperitoneally with 65mg/kg STZ. Confirmed diabetic dyslipidemic animals were treated intragastrically with CCE at doses of 250, 500, and 1000mg/kg, with 5mg/kg atorvastatin, and with 600µg/g glibenclamide for 30 days. Results: The extract, which tested positive for tannins, saponins, alkaloids, flavonoids, etc. lowered fasting blood glucose and glycosylated hemoglobin levels, and dose-dependently decreased the serum levels of T-chol, LDL, VLDL, and -HMG-CoA reductase, while simultaneously increasing HDL levels. The AIP was lowered in a dose-dependent manner by 33, 43.7, and 52.4% in groups treated with 250, 500, and 1000 mg/kg of CCE respectively. Conclusion: The results indicate that the C. citratus extract had an ameliorative effect on hyperglycemia, hyperlipidemia, obesity, and atherogenic index of plasma.
Authors and Affiliations
Christopher E. Ekpenyong, Koofreh Davies, Ekaette Etim Antai
Keywords
Related Articles
- EP ID EP348974
- DOI 10.9734/BJMMR/2014/11262
- Views 85
- Downloads 0
Pathophysiological Changes by Short-term Food Restriction in Obese Diabetic Rats
Aim: Reduced calorie intake by food restriction leads to extension of life span by exerting beneficial effects on metabolism. Zucker diabetic fatty (ZDF) rat is a type 2 diabetic model with obesity, showing the incidence...
The Evaluation of Osteosarcoma and Ewing Sarcoma by Bone Markers in Children and Adult after Chemotherapy
Background: In the east of Algeria, the rate of bone tumors is very high, unfortunately the Pathological Anatomy and radiology are not sufficient for evaluation and confirmation of the diagnosis. Bone alkaline phosphatas...
An Alternative Approach for Very High-risk Non-operative Patients with Severe Aortic Stenosis and Multivessel Coronary Disease - Staged Coronary Angioplasty and Transcatheter Aortic Valve Implantation – Case Report and Review of Literature
The Aim: The management of obstructive coronary artery disease before the transcatheter aortic valve implantation (TAVI) is not yet well established. Presentation of Case: We describe a 68-year-old patient with severe ao...
Serum Levels of Interleukin-2 and Interleukin-2 Soluble Receptor in Patients with Vitiligo
Background: Vitiligo is a common skin disorder characterized by macular depigmentation of the skin. Although the etiopathogenesis of the disease is still unclear, several studies have shown that within the cascade of pat...
The Effect of the Oral Bacterial Extract OM-85 BV on Asthma Control- a Prospective Study
Aims: To identify the effect of the oral bacterial extract OM-85 on essential parameters of asthma control. Study Design: This was a double blind, prospective study, consistent of a 4 week run-in and a 24 week double bli...