CYP3A4 Mediates Oxidative Metabolism of the Synthetic Cannabinoid AKB-48
Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 5
Abstract
The online version of this article (doi:10.1208/s12248-015-9788-7) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Niels Bjerre Holm, Line Marie Nielsen, Kristian Linnet
Keywords
Related Articles
- EP ID EP681005
- DOI 10.1208/s12248-015-9788-7
- Views 46
- Downloads 0
Interactions of Everolimus and Sorafenib in Pancreatic Cancer Cells
Everolimus targets the mammalian target of rapamycin, a kinase that promotes cell growth and proliferation in pancreatic cancer. Sorafenib inhibits the Raf-mitogen-activated protein kinase, vascular endothelial growth fa...
Influence of solvents on the variety of crystalline forms of erythromycin
The influence of the organic solvents widely used in the pharmaceutical industry (acetone, methylethylketone, ethanol, and isopropanol) both in the presence and in the absence of water on the crystallization behavior of...
Pharmacodynamic Model of Parathyroid Hormone Modulation by a Negative Allosteric Modulator of the Calcium-Sensing Receptor
In this study, a pharmacodynamic model is developed, based on calcium–parathyroid hormone (PTH) homeostasis, which describes the concentration–effect relationship of a negative allosteric modulator of the...
Ophthalmic drug design based on the metabolic activity of the eye: Soft drugs and chemical delivery systems
Despite its apparent easy accessibility, the eye is, in fact, well protected against the absorption of foreign materials, including therapeutic agents, by the eyelids, by the tearflow, and by the permeability barriers im...
Regulator of G Protein Signaling 17 as a Negative Modulator of GPCR Signaling in Multiple Human Cancers
Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS pro...