CYP3A4 Mediates Oxidative Metabolism of the Synthetic Cannabinoid AKB-48

Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 5

Abstract

The online version of this article (doi:10.1208/s12248-015-9788-7) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Niels Bjerre Holm, Line Marie Nielsen, Kristian Linnet

Keywords

Related Articles

In vitro evaluation of chitosan-EDTA conjugate polyplexes as a nanoparticulate gene delivery system

It was the purpose of this study to evaluate the potential of different molecular-weight chitosan-EDTA conjugates as a carrier matrix for nanoparticulate gene delivery systems. Covalent binding of EDTA to more than one c...

Prevention of Collagen-Induced Platelet Binding and Activation by Thermosensitive Nanoparticles

Peripheral artery disease is an atherosclerotic occlusion in the peripheral vasculature that is typically treated via percutaneous transluminal angioplasty. Unfortunately, deployment of the angioplasty balloon damages th...

Pulmonary Immunization of Guinea Pigs with Diphtheria CRM-197 Antigen as Nanoparticle Aggregate Dry Powders Enhance Local and Systemic Immune Responses

This study establishes the immune response elicited in guinea pigs after pulmonary and parenteral immunizations with diphtheria CRM-197 antigen (CrmAg). Several spray-dried powders of formalin-treated/untreated CrmAg nan...

The Use of Modeling Tools to Drive Efficient Oral Product Design

Modeling and simulation of drug dissolution and oral absorption has been increasingly used over the last decade to understand drug behavior in vivo based on the physicochemical properties of Active Pharmaceutical Ingredi...

Aggregation Kinetics for IgG1-Based Monoclonal Antibody Therapeutics

Monoclonal antibodies (mAbs) as a class of therapeutic molecules are finding an increasing demand in the biotechnology industry for the treatment of diseases like cancer and multiple sclerosis. A key challenge associated...

Download PDF file
  • EP ID EP681005
  • DOI  10.1208/s12248-015-9788-7
  • Views 63
  • Downloads 0

How To Cite

Niels Bjerre Holm, Line Marie Nielsen, Kristian Linnet (2015). CYP3A4 Mediates Oxidative Metabolism of the Synthetic Cannabinoid AKB-48. The AAPS Journal, 17(5), -. https://europub.co.uk/articles/-A-681005