Cystatin C- An Early Diagnostic Biomarker of Diabetic Kidney Disease
Journal Title: International Journal of Biochemistry Research & Review - Year 2016, Vol 11, Issue 3
Abstract
Aim: This study aimed to evaluate serum cystatin C vs. Serum creatinine and BUN as a potential better marker for early diagnosis of diabetic kidney disease. Study Design: Cross-sectional study. Place and Duration of Study: Department of Biochemistry, LTM Medical College, Sion, Mumbai, between January 2014 and November 2014. Methodology: Diagnosed patients of type 2 diabetes mellitus were evaluated based on detailed history, clinical examination and laboratory investigations. Patients having frank proteinuria were excluded. Patients without proteinuria were tested for microalbuminuria. In study group, we included 50 patients having microalbuminuria and in control group, 50 patients without microalbuminuria. Blood urea nitrogen (BUN), serum creatinine and serum cystatin C were estimated. Results were analysed by unpaired t-test & P-value was determined. Results: Serum cystatin C was found to be increased in the study group as compared with controls and the difference was statistically significant (P = .000). BUN (P = .26) and serum Creatinine (P = .11) were found to be slightly higher in cases compared to control group but values were within reference range. Conclusion: The results of this study suggest that serum cystatin C measurement is a useful, practical tool for the evaluation of renal involvement in the course of diabetes. BUN and serum creatinine values are affected by many factors like age, sex, muscle mass, diet. Serum cystatin C estimation offers a hope that diabetic kidney disease can be well prevented with appropriate interventions.
Authors and Affiliations
Sudarshan N. Shelke, Pramod W. Ingale, Pooja S. K. Rai, Shimi Sundharan
Keywords
Related Articles
- EP ID EP351201
- DOI 10.9734/IJBCRR/2016/24760
- Views 135
- Downloads 0
Defatted Soya Flour Supplementation of Wheat Bread Confers Oxidative, Renal, Hepatic and Cardiovascular Protective Effects in Wistar Rats
Background: The present study was designed to ascertain the effect of supplementation of bread with defatted soy flour on antioxidant, renal, hepatic and cardiovascular status in Wistar rats. Methods: Hard wheat flour w...
Study of Genetic Diversity among Different Tomato (Lycopersicum esculentum Mill.) Lines through Morphological and Biochemical Analysis
Aims: The aims of this study were to characterize the existing genetic diversity from Azad Jammu & Kashmir and to identify some selectable markers based on total leaf protein profiles. The purpose of the investigation wa...
Hypoglycemic Effects of Corn Steep Liquor Extracts in Streptozotocin-induced Diabetic Rats
Aims: The three plants presented in this study are Citrullus colocynthis, Gladiolus psittacinus and Circuligo pilosa. Their corn-steep fermenting liquor is traditionally used in preparing concoctions and decoctions for t...
Varietal Differences among the Phenolic Contents and Antioxidant Activities of White and Red Fleshed Guava during Maturation and Ripening Stages
Guava (Psidium guajava L.) is an important commercial fruit in southern China. In this study, the antioxidant activity and total contents of phenolics and flavonoids of two guava cultivars that with different pulp color...
Effect of Drying Methods and Storage Conditions on Nutritional Value and Sensory Properties of Dehydrated Tomato Powder (Lycopersicon esculentum)
The effects of two drying methods, (oven drying and sun drying) of tomatoes and storage conditions of the products were studied to assess their effects on chemical, nutritional quality and sensory properties. Eleven kilo...