Cyto-histo correlation of conventional Pap smear with cervical biopsy in diagnosis of precancerous and cancerous lesions of cervix
Journal Title: IP Archives of Cytology and Histopathology Research - Year 2018, Vol 3, Issue 2
Abstract
Introduction Carcinoma of uterine cervix is the third most common cancer among women worldwide and it contributes significantly to cancer related morbidity and mortality The incidence of cervical carcinoma is incredibly high in developing countries almost 80 due to lack of proper knowledge The extensive use of cervical screening with Pap smears has considerably increased the detection of precancerous and cancerous lesions of uterine cervixAims To evaluate cytohisto correlation of precancerous and cancerous lesions of uterine cervix and to calculate the sensitivity and specificity of Pap smear in diagnosing invasive malignancyMaterials and Methods This was a retrospective observational study conducted in the Department of Pathology Chirayu Medical College Hospital Bhopal from January 2013 to April 2018 All the cases reported in Pap smear as cervical intraepithelial lesions and invasive malignancies were retrieved We also retrieved the same cases if they had undegone cervical biopsy for correlationResult During the study period total 303 cases which were positive for intraepithelial lesions and malignancies were retrieved Out of these 303 cases we excluded 23 cases because in these cases cervical biopsy had not been done So in the final analysis 280 cases were included Of the 280 Pap smears maximum cases 3392 were reported as low grade squamous intraepithelial lesion LSIL followed by high grade squamous intraepithelial lesion HSIL 2428 atypical squamous cells of undetermined significance ASCUS 1964 atypical squamous cells cannot rule out HSIL ASCH 10 We had 23 cases of invasive malignancy which includes 21 cases of squamous cell carcinoma SCC and 2 cases of adenocarcinoma There were 11 cases of atypical glandular cells of undetermined significance AGUS We found that total numbers of concordant cases were 6857 192280 and discordant cases were 3143 88280 We also found that sensitivity and specificity of cervical smear in diagnosing invasive malignancy were 6176 and 991 respectively considering cervical biopsy as gold standardConclusion The study revealed a good correlation between cervical cytology and cervical biopsy We also concluded that conventional Pap smear is cost effective test for the early detection of precancerous and cancerous cervical lesionsKeywords Conventional Pap smear Cervical biopsy Cervical intraepithelial lesions CIN Low grade squamous intraepithelial lesion LSIL High grade squamous intraepithelial lesion HSIL
Authors and Affiliations
Farha Jalaly Meenai, Shabana Andleeb Ansari, Sonam Gupta, Manal Ashraf Ali
Keywords
Related Articles
- EP ID EP490547
- DOI 10.18231/2456-9267.2018.0016
- Views 70
- Downloads 0
Retrospective histopathological analysis of cervical cancer: Our experience
Introduction: Cervical cancer is a malignant neoplasm arising from the uterine cervix. One of the most common symptoms of cervical cancer is abnormal vaginal bleeding, but in some cases there may be no obvious symptoms u...
Endometrial histopathology in abnormal uterine bleeding
Introduction: In routine practice abnormal uterine bleeding (AUB) is a distinct entity. In women of reproductive age with episodic unpredictable bleeding it is an indication of number of pathologic disorder. Histopatholo...
Significance and Incidence of KRAS Mutations in Colorectal Carcinoma and Precancerous Lesions-A Retrospective Study in a Tertiary Care Centre
Introduction: KRAS mutation occurs in colorectal cancers in about 35%-45% cases. Colorectal carcinoma develops from precursor lesions and KRAS mutations occur early in carcinogenesis. KRAS mutation status can help to pre...
A case series on tuberculous mastitis
Background: Although Tuberculosis is a very common disease in developing countries like India but tuberculous mastitis is not very common as breast tissue is remarkably resistant to tuberculosis as the environment there...
Clinicopathological study of recipients’ corneal tissue excised during penetrating keratoplasty. Best out of waste!
Introduction Corneal buttons removed during penetrating keratoplasties PK from recipients which were routinely discarded were studied with aim to analyze the common indications of PK and changing pattern of corneal disea...