Cytochrome P-450 Polymorphisms and Clinical Outcome in Patients with Non-Small Cell Lung Cancer
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2017, Vol 14, Issue 3
Abstract
Lung cancer is an increasing worldwide public health problem. Most patients with lung cancer have non-small cell lung cancer (NSCLC). These patients are mainly treated with standard platinum-based chemotherapy. Poor response and great inter-individual variety in treatment response occurs among these patients. There is accumulating evidence to support the hypothesis that genetic polymorphisms alter the drug response and survival. Cytochrome P450 (CYP) enzymes metabolize antineoplastic drugs and are involved in drug resistance. Polymorphic CYPs have altered enzyme activities and thus they may influence the response to chemotherapy and survival in patients with lung cancer. In the current review, recent findings with respect to the role of mainly CYP1A1, CYP1B1, CYP2D6, CYP2E1 and CYP3A4 gene polymorphisms in response to chemotherapy and survival in patients with NSCLC have been provided, which could be useful for clinicians in the prognosis of these patients who are mainly treated with platinum-based chemotherapy.
Authors and Affiliations
Mümtaz İŞCAN, Ahmet Oğuz ADA
Keywords
Related Articles
- EP ID EP380980
- DOI 10.4274/tjps.28291
- Views 139
- Downloads 0
A Simple Isocratic High-perfomance Liquid Chromatography Method for the Simultaneous Determination of Shikonin Derivatives in Some Echium Species Growing Wild in Turkey
Objectives: Dried roots of Echium species are used in Turkey for the treatment of wounds, inflammation, and depression. In this study, an reversed-phase-liquid chromatographic method with isocratic elution was developed...
Comparative Anatomical Studies on Three Endemic Ononis L. (Leguminosae) Species Growing in Turkey
Objectives: The leaf and stem anatomical characteristics of three endemic Ononis L. (Leguminosae) species were studied for the first time for the evaluated in terms of systematic of similarities and differences in these...
Histone Deacetylase Inhibitors: A Prospect in Drug Discovery
Cancer is a provocative issue across the globe and treatment of uncontrolled cell growth follows a deep investigation in the field of drug discovery. Therefore, there is a crucial requirement for discovering an ingenious...
Some New Hydrazone Derivatives Bearing the 1,2,4-Triazole Moiety as Potential Antimycobacterial Agents
Objectives: The aim of this study was to synthesize, characterize, and screen some new 1-(4-((2-(4-substitutedphenyl)hydrazono)methyl)phenyl)-1H-1,2,4-triazole derivatives for their antimycobacterial activities. Material...
Anti-Angiogenic Activity of Flunarizine by In Ovo, In Vitro, and In Vivo Assays
Objectives: The involvement of T-type calcium channels in cell proliferation and the role of sodium channels in cell migration have been extensively studied in angiogenesis. In the present study, flunarizine, a dual sodi...