Cytogenetic Studies of Chromosome Abnormalities in Thyroid Cancer Patients Before and After Iodine-131 Treatment
Journal Title: Bezmiâlem Science - Year 2019, Vol 7, Issue 2
Abstract
Objective: Thyroid cancer is among the most common endocrine malignancies. Initial management consists surgery and ablation. I-131,which is used to damage surgically unremoved thyroid tissue or treat metastases, is a source for ionizing radiation (IR), also generates potential mutagenic and carcinogenic effects.The purpose of research is to investigate the damage on chromosomes at the I-131 treatment of thyroid cancer patients exposed to the same dose of genotoxic agent. Methods: Peripheral blood of 20 patients and 20 healthy control individuals were used in study. Materials were collected from patients before the I-131 treatment and three times on the 15th day, the first and second month after the I-131 treatment. All chromosome abnormalities, spontaneous chromosomal breakages, and sister chromatid exchange (SCE) were analyzed by cytogenetic methods in the samples. Results: The results obtained from peripheral blood of patiens who received ablation therapy revealed no significant increase for chromosome breakages, chromosome abnormalities, and SCE. Karyotyped metaphase spreads showed none of the structural and numerical chromosome abnormalities.The results of chromosome breakages and SCE have been statistically assessed by Aspin Welch test and did not differ from the control group.The t values of this variability were found to be -1.001,-1.654, respectively, and p>0.05. Conclusion: Our results demonstrate that applied therapeutic clinical dose does not show cytogenetic abnormalities risks of the early period in patients. I-131 treatment is a good option for the treatment of thyroid cancer,but also we recommend that physicians should perform long term follow-up examinations for IR exposed patients and prevent possible complications.
Authors and Affiliations
Seda ÖDEN, Sezen ATASOY, Mustafa DEMİR, Ayhan DEVİREN
Keywords
Related Articles
- EP ID EP49063
- DOI 10.14235/bas.galenos.2018.2571
- Views 298
- Downloads 0
Asymmetric Blepharospasm Treated with Botulinum Toxin-A: Case Report
Benign essential blepharospasm (BEB) is a focal dystonia that causes involuntary occlusion of the eyelids as result of bilateral contraction of orbicularis oculi muscle. A 51-year-old female patient evaluated at the outp...
Cytogenetic Studies of Chromosome Abnormalities in Thyroid Cancer Patients Before and After Iodine-131 Treatment
Objective: Thyroid cancer is among the most common endocrine malignancies. Initial management consists surgery and ablation. I-131,which is used to damage surgically unremoved thyroid tissue or treat metastases, is a sou...
New Diagnosis Diabetes and Deep Venous Thrombosis with Glucagonoma Cases; Case Report
Glucagonomas; is a rare neuroendocrine tumor originating from alpha cells of the pancreas. Glucagonoma syndrome is a paraneoplastic entity known as diarrhea, weight loss, stomatitis, thrombosis, diabetes, and necrotizing...
Development and Validation of an In Vitro Dissolution Method Based on HPLC Analysis for L-Dopa Release From PLGA Nanoparticles
Objective: In the past decade, dissolution testing has emerged as a valauble tool for the characterization of drug product performance in the field of pharmaceuticals. During the development of new formulations, dissolut...
Validation of Turkish Version of Newest Vital Sign Scale to Assess Health Literacy
Objective: The aim of the study was to check Turkish validation of the Newest Vital Sign (NVS) scale. Methods: The participants were composed of the patients who were registered in a Family Health Center located in Burs...