CYTOGENETICS FINDINGS OF PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN WEST INDIAN REGION.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 2
Abstract
Acute lymphoblastic leukemia (ALL) is one of the most common malignancies in India. Detection of chromosomal abnormalities by conventional karyotyping and Fluorescent in situ hybridization (FISH) plays a very important role in classification and treatment of ALL patients. The aim of this study was to define the frequency and types of chromosomal aberrations in B-ALL patients of West India. In this study, we analyzed bone marrow samples of 35 (18 adults and 17 childhood) West Indian patients with B-ALL using the conventional G-banding and FISH technique. Total 24 patients (68.57%) showed chromosomal alterations, including numerical and/or structural abnormalities. Hyperdiploidy was most common (11.43%) numerical abnormality while the most common fusion oncogenes were BCR-ABL1/t(9;22) in adults (33.33%) and ETV-RUNX1/t(12;21) in children (23.53%). The incidence of 11q23 and t(1;19) were also high than those reported in the previous studies. There was a difference in the prevalence of abnormalities in the current study, maybe due to the geographical variation and/or small sample size.
Authors and Affiliations
Pankaj Gadhia
Keywords
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- EP ID EP277954
- DOI 10.21474/IJAR01/6473
- Views 64
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