CYTOHISTOPATHOLOGICAL CORRELATION OF SOFT TISSUE TUMORS: A RETROSPECTIVE STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 27
Abstract
INTRODUCTION: Fine Needle Aspiration Cytology is well established technique for evaluation of epithelial tumors for many years. Now it has gained its reputation in the diagnostic work up of soft tissue tumors as well. In our study we assessed a total of 252 cases of soft tissue tumors by Fine Needle aspiration cytology during a period of two years 2009-2011 and the patients were followed up for biopsies for histopathological correlation. The initial diagnosis of many mass lesions, both superficial and deep-seated, can often be readily and safely assessed by FNAC. AIMS AND OBJECTIVES: 1. To study the age, sex and site-wise distribution of soft tissue tumors. 2. To assess the role of Fine Needle Aspiration Cytology in diagnosing various types of soft tissue tumors. 3. To assess the sensitivity, specificity, positive and negative predictive values, and overall histological correlation percentage of Fine Needle Aspiration Cytology in diagnosing soft tissue tumors. MATERIALS AND METHODS: Aspirations were done using a 22 gauge disposable needle and a 10c.c disposable syringe for suction. Wet-fixed smears with isopropyl alcohol were stained with hematoxylin and eosin. Dry-fixed smears were stained with May- Grunwald Giemsa were studied for cytological details and diagnosis. The excised surgical specimen and biopsies of the above cases were processed routinely and stained with Hematoxylin and Eosin. RESULTS: Total 252 cases were studied from Aug 2009 to July 2011 retrospectively. Out of these we received excised specimen and biopsies for 216 cases. Remaining 36 cases were excluded in our study as we could not trace the patient for biopsies. 180 were diagnosed as benign soft tissue tumors, while 36 were diagnosed as malignant on cytological examination. The median age of benign soft tissue tumors was 35 years, while that of malignant soft tissue tumors was 40years. Prevalence was highest in the age group of 21-40 years, during which majority were benign lesions. Soft tissue tumors were more common in the lower extremities with predominant benign tumors, while malignant tumors were more common in the trunk. Sex wise distribution showed a male: female ratio of 1.18:1, indicating that they were more common in males. The most common tumors were lipomas, followed by Hemangiomas and peripheral nerve sheath tumors. A comparative analysis was done between the cytology report and histopathology. CONCLUSION: Final evaluation of the results showed that the diagnostic accuracy of FNAC of soft tissue tumors according to the present study was 95.37%, sensitivity was 84.2% and specificity 97.75%. Thus our study proves the efficacy of FNAC in the diagnosis of soft tissue tumors as a useful cost-effective procedure.
Authors and Affiliations
Vijayabharathi I, Bhagyalakshmi A, Ramesh U, Manasa R
Keywords
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- EP ID EP230998
- DOI 10.18410/jebmh/2015/572
- Views 86
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