Cytokine Production by Circulating Endothelial Progenitor Cells before and after G-CSF Mobilization
Journal Title: Studies on Stem Cells Research and Therapy - Year 2016, Vol 2, Issue 1
Abstract
Objective: Bone marrow-derived circulating endothelial cells (EPCs) may migrate in ischemia zone, to stimulate resident progenitor cells to proliferation, differentiation and migration in a damage zone, and reduce an ischemia zone through formation of new vessels. Granulocyte colony stimulating factor (G-CSF) is well established to mobilize hematopoietic stem cells and might, thereby, also increase the pool of endogenously circulating EPCs. EPCs secrete pro-angiogenic factors. Therefore, we investigated the effects of G-CSF administration on mobilization and functional activities of blood-derived EPC in patients with chronic ischemic heart disease (CIHD).
Authors and Affiliations
Lykov Alexander, Poveschenko Olga, Bondarenko Natalia, Kim Irina, Pokushalov Eugenie, Romanov Alexander, Konenkov Vladimir
Keywords
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- EP ID EP558532
- DOI 10.17352/sscrt.000006
- Views 46
- Downloads 0
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