Cytokines and anti-cytokine therapy in periodontal disease
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Periodontal disese is initiated by the presence of bacteria on tooth surface but it is the host response that helps in progression of disease. An intermediate mechanism that lies between bacterial stimulation and tissue destruction is the production of cytokines, which stimulates inflammatory events that activate effector mechanisms. There are various classes of cytokines depending on their chemical structure and origin. Owing to the unique mechanism of action, these micromolecules play a very important part in immune host defence. Anticytokine therapy for periodontal diseases especially targets proinflammatory cytokines, that is, TNF-α, IL-1, and IL-6, because these are essential for the initiation of the inflammatory immune reaction and are produced for prolonged periods in periodontitis. This therapy aims to bind the cytokines with the receptors present on target cells such as the fibroblasts.
Authors and Affiliations
Agraja Patil, Swapna Mahale
Keywords
Related Articles
- EP ID EP592611
- DOI 10.9790/0853-1603026370
- Views 69
- Downloads 0
Maternal and Fetal Outcomes in Hypertensive Disorders Of Pregnancy in a Tertiary Care Hospital- A Prospective Study
INTRODUCTION: Hypertensive disorders complicate 5-10% of all pregnancies, often associated with maternal and fetal mortality and morbidity. This study is aimed at knowing the effect of hypertensive disorders of pregnancy...
Pulmonary function test with DAS28 score and duration of Rheumatoid arthritis: A comparative analysis
Background: Pulmonary involment in Rheumatoid arthritis is major health concern in the field of rheumatology. Evidence suggests one of commonest cause of mortality in RA. Objective: We found the abnormalities of pulmonar...
A Comparison of Smear versus QBC and Rapid Malaria card tests as diagnostic tool for Malarial parasites.
Introduction: In malaria patients, a prompt and accurate diagnosis is the key to effective disease management. In order to identify a quick and reliable technique for accurate diagnosis of malaria this study has been con...
Different Clinical Presentation of Corpus Lutealcyst Haemorrhage:Case Report
The corpus luteum is a temporary hormone secreting remnant formed after rupture of a mature ovarian follicle to release an ovum. Sometimes, it may fill with blood or other fluids, forming a cyst and rupture in rare cases...
Clinical Innovation--Intruding Molar with Spring Loaded Removable Appliance
.