Cytological Diagnosis of Rosai-Dorfman Disease in Region of Neck
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 12
Abstract
Introduction: The disease was first described by Rosai and Dorfman in 1969. Also known as Sinus Histiocytosis with Massive Lymphadenopathy (SHML). Patients presenting with lymphadenopathy are commonly diagnosed as having tuberculosis or malignant lymphomas, whereas cases with extra nodal involvement are suspected of having various neoplasms, depending on site of involvement. Cytological features of SHML are virtually diagnostic and can obviate the need for biopsy in most cases. Objective: To study the FNAC findings for diagnosis of this rare disease. Case: The patient in our case was a young male who presented with massive cervical lymphadenopathy, fever, leukocytosis, hypergammaglobulinemia and raised ESR. The patient was clinically diagnosed as having lymphoma or tuberculosis. Materials and methods: FNAC was done and the smears were stained by May-Grunwald Giemsa stain. Observations: Smears were cellular and showed presence of mixed population of small and large lymphocytes, diffusely distributed histiocytes having single or multiple nuclei with fine chromatin, pale cytoplasm and exhibited numerous intact lymphocytes and polymorphs (Emperipolesis). Many foreign body giant cells, few plasma cells and large number of degenerated cells were also seen. Based on this characteristic cytomorphology a diagnosis of Rosai Dorfman Disease was made. Conclusion: Thus, fine needle aspiration cytology is a useful and reliable tool for the diagnosis of RosaiDorfman disease due to which biopsy can be avoided.
Authors and Affiliations
Dr. Dipti Panwar
Keywords
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