CYTOMORPHOLOGICAL ANALYSIS OF LYMPH NODE PATHOLOGY IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 73
Abstract
BACKGROUND Lymph node pathology includes a wide range of diseases, which ranges from inflammatory lesion to lymphoma and metastatic deposits. Even though, the biopsy yields the confirmed diagnosis. FNAC maybe the only test, which gives a preliminary diagnosis, gives idea to further management and treatment in some cases particularly in malignant deposits and chronic granulomatous diseases like tuberculosis. FNAC is an outpatient procedure, which needs minimal manpower and no need of surgical intervention or anaesthesia. In this descriptive study, we analyse the presentations of lymphadenopathy cases in cytology, categorise the diagnosis and compare the FNAC findings with the histopathological diagnosis and assess the efficacy of the FNAC test in lymph node pathology. MATERIALS AND METHODS In this descriptive study, we took FNA cases sent to our Pathology Department with signs of lymph node enlargement. Patients presented with lymph node enlargement in the sites of cervical, axillary, supraclavicular, inguinal and multiple sites were included in this study. Cases were selected from January 2015 to December 2016. Cases with inadequate material and improper staining were excluded. We use 22-23G needle with 10 mL disposable syringe for aspiration. Smears were made, fixed in isopropyl alcohol and stained with routine H and E, if necessary Giemsa stains were used. The cytological diagnoses were correlated with histopathological diagnosis. Immunohistochemistry was done in relevant cases to confirm the diagnosis. RESULTS A total no. of 1842 FNAC cases were received in our Pathology Department during the period between January 2015 to December 2016. The age distribution was between 1 year to 80 years. The lymph node enlargement was more common in males than in females. In the cytological cases, certain discrepancies observed with the referring surgeon regarding the diagnosis. Out of 4 cases, 2 were lymphoproliferative disease and 2 cases of metastatic deposits were referred for IHC study. In the IHC study, 4 cases of lymphoproliferative disease were confirmed as NHL and 2 cases of secondary metastatic deposits, which was in discrepancy with clinicians as lymphoma were confirmed by IHC as carcinomatous deposits. CONCLUSION Based on the study, FNAC is the first line of investigation and helpful procedure in the diagnosis of neoplastic and nonneoplastic lesions of the lymph node. FNAC is not only useful in the diagnosis of various lesions of lymph node and also open the gateway for the clinicians in the management of the lymph node pathology.
Authors and Affiliations
Kavitha Duraisamy, Dhamayanthi Surya Moorthy, Revathi Ramakrishnan
Keywords
Related Articles
- EP ID EP265823
- DOI 10.14260/Jemds/2017/1132
- Views 66
- Downloads 0
GENDER-BASED DIFFERENCES IN THE BLEEDING TIME AND CLOTTING TIME AND THEIR RELATIONSHIP WITH THE BLOOD GROUPS
BACKGROUND The clinical significance of the ABO blood group system extends beyond transfusion medicine. It is remarkable that 100 years after the work of Karl Landsteiner (1900) on blood grouping, the scene is different...
EPISTAXIS- CONTRIBUTORY AND ASSOCIATED FACTORS AND MANAGEMENT
BACKGROUND Epistaxis is the most common otolaryngologic emergency and affects up to 60% of the population in their lifetime, and 6% require medical attention. The variability of severity can range from outpatient managem...
DETECTION OF ACQUIRED MULTIDRUG-RESISTANT TUBERCULOSIS AND EXTENSIVELY DRUGRESISTANT TUBERCULOSIS IN AND AROUND KOLKATA IN RECENT PAST
BACKGROUND Nowadays tuberculosis is a serious global problem. There is an estimated 8-10 million new cases of tuberculosis worldwide with 2- 3 million deaths occurring in each year. In many parts of the world, including...
COMPOUND DORSAL GANGLION WITH RICE BODIES
[b]BACKGROUND:[/b] Tuberculosis has decreased persistently since the introduction of antituberculous chemotherapy. However there are reports in recent literature indicating that rate of tuberculosis is increa...
TESTICULAR FEMINISING SYNDROME
Testicular feminization syndrome is a form of pseudohermaphroditism where phenotypic female has male gonads and is genotypically male. Androgen insensitivity syndrome (AIS), also known as testicular feminization, enc...