CYTOPATHOLOGIC STUDY OF PERITONEAL FLUIDS IN CONTEXT OF CONVENTIONAL SMEARS VERSUS CELL BLOCKS
Journal Title: PARIPEX-Indian Journal of Research - Year 2019, Vol 8, Issue 5
Abstract
Cytopathologic study of body cavity effusions is one of the common ways to reach a definitive diagnosis. The major drawback in conventional smear(CS) cytology is the difficulty to differentiate reactive and malignant mesothelial cells and also loss of morphologic details. Cell block(CB) technique is a very old and cost effective method, but seldom prescribed by physicians. There are few studies where both the techniques CS and CB are compared for diagnostic yield in benign as well as malignant cases simultaneously. This study was undertaken to compare the morphological details and diagnostic yield of CS and CB techniques on peritoneal effusions. A one year prospective study was conducted in Government Medical College, Datia(M.P.) on cases presenting with peritoneal effusions. The study population was 94.CS cytology were stained with Papanicolaou as well as May- Grunwald Giemsa. The CB specimens were fixed in 10% alcohol-formalin and further processed as tissue specimen .The cytopathologic study was correlated with clinical details for final diagnosis. The diagnostic yield was seen better with CB (p valu- 0.04)in malignant cases with no significant difference in benign cases. On comparative analysis, CB was a better technique in preservation of architecture, morphological details and recognition of malignant mesothelial cells over reactive cells. , thereby increasing the sensitivity of the test.. So, the use of cell blocks can easily be used as an additive test to CS cytology without any extra procedure on patient.
Authors and Affiliations
Dr. Shweta Shrivastava, Dr. Dwijendra Nath, Dr. Rajesh Gaur, Dr. Shruti Singh
Keywords
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