Cytotoxic Activity of Secondary Metabolites from the Bark of Dipterocarpus Confertus Sloot
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 9, Issue 1
Abstract
Four compounds, namely β-sitosterol (1), betulinic acid (2), cinnamic acid (3), and α-viniferin (4) have been successfully isolated from the bark methanol extract of Dipterocarpus confertus Sloot. The structures of the isolated compounds have been established on the basis spectroscopic data evidence, and comparison with the published data. In the cytotoxicity study, cinnamic acid (3) and betulinic acid (2) have been found to be very strong active against murine leukemia P388 and vero cells lines with the IC50 values of 2.25 and 5.10 µg/mL, respectively, while the other compounds were not active.
Authors and Affiliations
Muhtadi Muhtadi, Peni Indrayudha, Agustono Wibowo, Dr Heng Yen Khong
Keywords
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- EP ID EP652690
- DOI 10.24297/jac.v9i1.2307
- Views 171
- Downloads 0
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