Cytotoxic and Anti-Cervical Cancer Effects of the Camellia sinensis Byproducts from Various Kenyan Factories
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2024, Vol 8, Issue 1
Abstract
Cervical cancer is a significant global health challenge and necessitates the search for innovative and patient-friendly therapies due to the limitations and challenges posed by conventional treatments. This study explored the largely overlooked potential of Camellia sinensis processing wastes as a natural source for developing effective and safe anticancer compounds. Tea waste samples from Kenyan processing facilities demonstrated concentration-dependent cytotoxic effects on normal epithelial cells (Vero), with the fluff sample from Chelal displaying superior efficacy. Median inhibitory concentration (IC50) values highlighted the potency of the samples, especially the fluff sample from Chelal (IC50: 483.99µg/ml). Selectivity indices revealed favorable safety profiles, indicating selective potential anticancer effects against cervical cancer cells. This study contributes substantively to understanding tea waste’s anticancer potential, providing valuable insights for drug development. The study offers a foundation for continued research into sustainable and impactful anticancer drug discovery, emphasizing specific results that pinpoint promising tea waste samples and their potential applications in cervical cancer therapy and anticancer drug development.
Authors and Affiliations
Thaddeus M*, Daniel K, Johnson K, Martin O, Simon O and Gervason M
Keywords
Related Articles
- EP ID EP751868
- DOI 10.23880/oajpr-16000297
- Views 2
- Downloads 0
Antihyperlipidemic and Antibacterial Activities of Baccaurea Courtallensis Leaves
The present study evaluated the antihyperlipidemic and antibacterial activities of B. courtallensis extract. The antihyperlipidemic effect of B. courtallensis methanol extract was studied in Triton WR-1339 and high fat d...
G-Reactor at Micro-Plant
The stirrer reactor govern the industrial pharmaceutical productions up to the present, however the complex transmission systems may increase the costs exponentially with the power rates and the hermetic rector sealing....
Mechanistic Insights of Rutin against Metabolic Disorders
Rutin, a quercetin glycoside comes under the class flavonol. The aglycone part of rutin is known as quercetin. It is found in numerous fruits and plants, especially apricots, buckwheat, cherries, grapefruit, grapes, ora...
Cannabinoid Receptor CB2 Subtype: A Novel Pharmacological Target in Cancer and Neurodegenerative Diseases
CB2 receptor (CB2R) is one of the canonical cannabinoid receptor belonging to endocannabinoid system (ECS). It was cloned for the first time in 1993 from the human leukemia cell line HL-60, and it is part of the G-protei...
C-termini Analysis of Monoclonal Antibody Fragmentation
Fragmentation of therapeutic monoclonal antibodies (mAbs) is a critical quality attribute (CQA) that needs to be monitored and controlled during the biopharmaceutical drug development. Fragmentation of a protein is a res...