Cytotoxic and antioxidant activity of selected marine sponges
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 3
Abstract
Objective: To evaluate the anticancer activity of the crude extracts of Rhabdastrella globostellata (R. globostellata) and Spirastrella inconstans (S. inconstans) var. moeandrina Dendy. Methods: Soxhlet extraction method was used to extract the secondary metabolites and various assays antioxidant, anticancer and various assays were carried out. The extract were tested anticancer activity against a HeLa, Raw 264.7 and Hek-293. Results: The sponge extracts tested exhibited from median to high toxicity in at least one of the toxicity bioassays performed. The antioxidant activity of the isolated metabolite in ethylacetate solution was assessed by SOD and GTH assays and compared with that of other known natural antioxidants. Conclusions: Potent antioxidants have been detected among both phenolic metabolites and alkaloids. Antioxidant effects of tested compounds have been attributed to their action as chain-breaking antioxidants and/or as scavengers of radicals
Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with aqueous extracts of Momordica charantia (karela) fruits
Objective: To investigate the effect of aqueous extract of Momordica charantia (karela) (M. charantia) fruits on blood glucose level, pancreatic weight changes and histopathology of pancreatic changes in the streptozotoc...
Nephroprotective effects of Colpomenia sinuosa (Derbes & Solier) against carbon tetrachloride induced kidney injury in Wistar rats
Objective: To establish the protective effect of seaweed Colpomenia sinuosa against carbon tetra chloride (CCl4) induced oxidative stress and resultant dysfunction of rat kidney. Methods: Seven to eight weeks old male Wi...
Application of geographical information system-based analytical hierarchy process as a tool for dengue risk assessment
Objective: To highlight the use of analytical hierarchy process (AHP) in geographical information system that incorporates environmental indices to generate dengue risk zonation area. Methods: The medical database consid...
Integration of HIV services into the National Tuberculosis Program of Cameroon: the experience of the Littoral Province
Objective: To evaluate the implementation of collaborative HIV/TB activities recommended by the World Health Organization in the Littoral Province of Cameroon from 2007 to 2009. Methods: Data from the tuberculosis (TB) a...
Macroscopial, anatomical and physico-chemical studies on fruits of Coccinia indica Wight &Arn. (Cucurbitaceae)
Objective: To rationalize the macroscopial, anatomical and physico-chemical studies on fruits of Coccinia indica Wight & Arn. (Cucurbitaceae). Methods: The crude ethanolic extract of fruits of Coccinia indica Wight & Arn...