Cytotoxic and genotoxic effects of a common food additive monosodium glutamate in mice: a preliminary report
Journal Title: International Journal of Experimental Research and Review - Year 2016, Vol 8, Issue 7
Abstract
In our present study we investigated if the Monosodium glutamate (MSG) has any cytotoxic and genotoxic effect in animal system by studying cytogenetical parameters, namely chromosome aberration (CA), mitotic indices (MI) and sperm head anomaly (SHA) and a histo-pathological parameter i.e., tissue weight / body weight ratio in mice. Experiments were carried out at three different fixation intervals, namely, 7D, 14D and 21D, maintaining suitable controls. MSG was administered to mice at the dose 2 mg / gm of body weight. The investigation reveals that feeding of MSG induced geno-toxicity and cyto-toxicity. These produced greater amount of CA, SHA along with a general increase in the MI at significant levels. Thus, the increased level of genotoxicity and cytotoxicity could be attributed due to chronic feeding of the food additive MSG.
Authors and Affiliations
Saikat Pramanik; Susanta Roy Karmakar
Keywords
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