Cytotoxic Effect of Lingzhi Extracts on Gefitinib-resitant Lung Cancer Cells
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 9, Issue 6
Abstract
Aims: The present study was carried out to investigate the cytotoxicity of extracts from Ganoderma and Amauroderma lingzhi species collected in Tay Nguyen, Vietnam. Methods: Mushroom samples were extracted by methanol and the cytotoxicity was performed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) method. Results: Among twelve extracts prepared from Ganoderma and Amauroderma species, six samples significantly inhibited the proliferation of gefitinib-resistant NSCLC cell lines NCI-H1975 and A549. Amauroderma rugosum exhibited cytotoxic effects against both cell lines in comparison with etoposide. Conclusion: The obtained results suggested that the Tay Nguyen lingzhi could be regarded as a promising candidate for natural sources of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs).
Authors and Affiliations
Nguyen Hai Dang, Pham Thanh Binh, Nguyen Thi Tham, Bui Thi Mai Anh, Nguyen Phuong Dai Nguyen, Nguyen Tien Dat
Keywords
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- EP ID EP342343
- DOI 10.9734/BJPR/2016/23005
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