Cytotoxic effect ofCladophoraglomeratacrude extracts andphytolin bone marrow of mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Cladophoraglomerata contain different active compounds like flavonoids, alkaloids, phenols and tannins, fatty acids, sterols, terpeneswhich could be used as a novel source of natural agents for pharmaceutical industries. Some Studies that determined the activity of immune system and the effects of different agents depended on the cells division in bone marrow as it is the source of all blood cells. Two different doses (50,150 mg/ kg) from algal crude extracts and phytol were used in this study to determine the activity of these extracts on Mitotic index and Blast index in mice bone marrow.The resultsrevealed that the Blast index (BI) of bone marrow had a significant differences and increased in the higher dose(15 mg/kg) of aqueous extract and phytolas compared with control group while in ethanolic extract no significant differences appeared in both doses. The decline in Mitottic index (MI) was evident on the cytotoxicity of the lower dose from aqueous extract.The results alsoshowed that the influence on increment of (MI) in ethanolic extract, indicated to the anticytotoxic effect of this extract. On the other hand, this study suggested, that the activity of ethanolic extract in these two parameters may be belonged to phytol, which did not show any significant differences with crude ethanolic extract when was used as a pure compound.
Authors and Affiliations
* Lamiaa A. Gharb1
Keywords
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- EP ID EP390340
- DOI 10.9790/3008-1204073943
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