CYTOTOXIC POTENTIAL OF HELLEBORUS PURPURASCENS L.
Journal Title: Analele Stiintifice ale Universitatii Alexandru Ioan Cuza din Iasi, Serie noua, Sectiunea II a. Biologie vegetala - Year 2016, Vol 62, Issue 2
Abstract
The genus Helleborus (Ranunculaceae), or hellebore, comprises around 20 species of perennial herbs native to Europe and Asia. Our investigations refer to the cytotoxic potential of Helleborus purpurascens L., based on the traditional use of this genus on several malignancies. The used alcoholic extract is subject to a national patent application (A/00285/2016). The in vitro assays conducted on two cancer cell lines Jurkat (a leukaemic T-cell line) and BT-20 (breast cancer cell line) exposed to alcoholic extract for 24 and 48 hours, respectively, confirmed that this plant is a potential antitumoral agent. The effect is dose-dependent and it is obvious that Jurkat cells are more sensible than BT-20 to exposure. The reference compound, 5-FU (50µg/mL), a widely used anticancer agent, acted slower, the cells viability decreasing from 30-55% after 24h of exposure to 10% after 48h. The studies should be continued in order to investigate the compound(s) in Helleborus extract responsible for cytotoxic action.
Authors and Affiliations
Alice GRIGORE, Georgeta NEAGU, Nicoleta DOBRE, Adrian ALBULESCU, Carmen IONITA, Lucian IONITA, Dana BOBIT
Keywords
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