Cytotoxicity and Antioxidant Potentials of Barringtonia Asiatica Essential Oil
Journal Title: Drug Designing & Intellectual Properties International Journal - Year 2018, Vol 2, Issue 2
Abstract
Essential oils are liquid mixture of volatile compound obtained from aromatic plants. It was observed that many essential oils have antioxidant properties and can present antimicrobial activities. The Aim of the present study were: a) to determine the cytotoxicity lethality of the leafs and stem-bark of Barringtonia asiatica using brine shrimp (Artimia salina). b) to evaluate the antioxidant potential of composition of the leaf and stem-bark essential oil using the DPPH (2,2-diphenyl-1- picrylhydrazyl) free radical scavenging assay. The essential oil exhibited a mild toxicity and significant IC50 of 36.55μg/mL and 22.10μg/mL value of antioxidant potential leaf and stem-bark of Barringtonia asiatica respectively.Right from ancient time drugs of plants have been used as herbal formulations in crude forms, like tinctures, teas, powders and poultices, for their growing interest as alternative therapies for the prevention or treatment of various diseases [1]. Essential oils from medicinal and aromatic plants are still considered as rich sources of a huge number of antimicrobial and antifungal components [2]. Many of them show a great potential as anticancer therapeutic agents [3]. However, essential oils are chemically characterized as complex mixtures of low molecular weight compounds and, some of them, are highly volatile and capable of generating flavors and aromas [4]. Scientific studies have shown the role of essential oils in biological interactions among plants and their potential therapeutic including anti-inflammatory, analgesic, anti-tumor, antifungal, and antibacterial activities [5- 9]. In addition to the above-mentioned properties, many essential oils have been confirmed to possess antioxidant activity. They are extremely important for disease prevention, since they inhibit and delay the oxidation of biomolecules by preventing the initiation or propagation of chain oxidation reactions [10-12]. Thus, because of the harmful effects that synthetic antioxidants may cause, such as toxicity and carcinogenicity, the interest in the discovery of natural antioxidants has increased considerably [13]. The growing interest in natural bioactive compounds has led to conduct further studies addressing the replacement of synthetic chemical agents in the industrial sector, since natural products are less harmful to health [14], in addition to being biodegradable and usually exhibiting low toxicity in mammals [15]. This plant Barringtonia asiatica was considered to extract and test for its cytotoxicity and antioxidant potentials. However, Barringtonia asiatica is one of the species belonging to the family Barringtonia, native to mangrove habitats on the tropical, it is a common plant in the Malaysian Mangroves and wetlands such as the Kuching wetlands Sarawak and Bako National Park, it is also found in tropical Africa, Nigeria and Madagascar. Other species belonging to this genus are Barringtonia racemosa, Barrington acutangula, Barringtonia edilus, Barringtonia lanceolate, Barringtonia macrostachya, and Barringtonia spicata [16]. The literature survey revealed that there are no scientific Citation: Isaac J U, Chinedu I, Kayode A, Silas V T, Hauwa A U. Cytotoxicity and Antioxidant Potentials of Barringtonia Asiatica Essential Oil. Drug Des Int Prop Int J 2(2). DDIPIJ.MS.ID.000131. DOI: 10.32474.DDIPIJ.2018.02.000131. 173 studies carried out regarding antioxidant and cytotoxicity of the essential oil of the leaves, stem- barks of Barringtonia asiatica. Hence, the present study is focused to evaluate the antioxidant potentials including determining cytotoxicity (leafs and stembarks) by using Artemia salina and 2,2-diphenyl-1-picrylhydrazyl.
Authors and Affiliations
Isaac John Umaru, Chinedu Imo, Kayode Arowora, Silas Verwiyah Tatah, Hauwa A Umaru
Keywords
Related Articles
- EP ID EP587713
- DOI 10.32474/DDIPIJ.2018.02.000131
- Views 135
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Cytotoxicity and Antioxidant Potentials of Barringtonia Asiatica Essential Oil
Essential oils are liquid mixture of volatile compound obtained from aromatic plants. It was observed that many essential oils have antioxidant properties and can present antimicrobial activities. The Aim of the present...