CYTOTOXICITY INVESTIGATION ON CULTURED CT3 CELLS TREATED WITH MWCNTS AND F-MWCNTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
Functionalised carbon nanotubes (f-MWCNTs), derived from Multiwalled carbon nanotubes (MWCNTs) was synthesized and examined their cytotoxicity effect in drug release applications. MWCNTs were synthesized by chemical vapor deposition over Fe -MCM-41 molecular sieves using acetylene as a carbon source. They were characterized by XRD, FT-IR, RAMAN, SEM, TEM and functionalized using H2SO4:HNO3 mixtures. The MWCNTs and f-MWCNTs were tested for “invitro” MTT assay on cultured CT3 cells at different concentrations (0, 5, 10, 15 and 20 mg/ml) for 12-72 hrs. The results confirmed that f-MWCNTs were less toxic than MWCNTs. This observation suggests the applicability of f-MWCNTs in drug release applications. For the treatment of Hyperlipidemia and cholesterol control, f-MWCNTs could be novel potential materials.
Authors and Affiliations
Malarvizhi A. , Pandurangan A.
Keywords
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