CYTOTOXICITY OF BYRSONIMA DUCKEANA W. R. ANDERSON (MALPIGHIACEAE) ON COLON CANCER CELLS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: The objective of this study was the cytotoxicity evaluation of the leaves extract and fractions of Byrsonima duckeana W. R. Anderson.Methods: The toxicity on Artemia salina, haemolytic potential and cytotoxicity activities against two different cell lines a U937 cell line human, and HT29 tumor colon cell line of the leaves extract and fractions of Byrsonima duckeana W. R. Anderson were evaluated.Results: There was no IC50 the Artemia salina assay. The chloroform and ethyl acetate fractions showed haemolytic activity. The results were satisfactory at the most polar fractions, with citotoxicity to the HT29 cell line.Conclusion: The study provides preliminary evidence of cytotoxicity of the most polar fractions at the HT29 cell line, which can indicate a potencial source to offer substances with cytotoxic activity.
Authors and Affiliations
Maria Christina Dos Santos Verdam, Fernanda Guilhon-simplicio, Cristiane Da Silva Paula, Vinicius Bednarczuk De Oliveira, Marilis Dallarmi Miguel, PatrÃcia Maria Stuelp Campelo, Obdulio Gomes Miguel
Keywords
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