Cytotoxicity on mcf7 cell lines exposed to an extract of the jacalin from jackfruit seed
Journal Title: Science Heritage Journal | Galeri Warisan Sains (GWS) - Year 2017, Vol 1, Issue 2
Abstract
Jacalin is a major lectin present in jackfruit seeds, obtained by crude protein recovery. Its lectin symbol is AIL and it belongs to the galactose family of N-acetylglucosamine binding lectins, which are recognized to be cancer cell inhibitor. There have been many pharmacological research studies focusing intensively on jacalin, however their scope was restricted to the application of jacalin in pharmacology. Jacalin or lectin extract from jackfruit seed were induced cell cycle arrest in human breast cancer cell, MCF7, in comparison of crude extract, purified jacalin and jacalin standard. IC50 for MCF7 was achieved at concentration 125 µg/mL, comparable to jacalin standard with only 1.60 % contradictions.
Authors and Affiliations
M. A Zuraidah, Akbar John, Y. Kamaruzzaman
Keywords
Related Articles
- EP ID EP257010
- DOI 10.26480/gws.02.2017.16.18
- Views 140
- Downloads 0
Pcb biodegration using bacteria isolated from landfill leachate
Polychlorinated biphenyls, PCBs are toxic, persistent organic pollutants (POP) which are harmful to human and environment due to their lipophilic characteristic and not easily degraded in the environment. Biodegradation...
DIVERSITY AND DISTRIBUTION OF FERN SPECIES IN SELECTED TRAIL IN KUANTAN PAHANG
A study on the diversity and distribution of terrestrial and epiphytic fern in Kuantan, Pahang was conducted from January to November 2017. Fourteen species of both terrestrial and epiphytic ferns, respectively have been...
The investigation of cytotoxic effect of cinnamomum zeylanicum extracts on human breast cancer cell line (mcf-7)
Cinnamon is one of the oldest herbal medicine that has been historically known to possess has anticancer property. In this study, the cytotoxicity of the cinnamon extracts towards human breast cancer cell line (MCF-7) wa...
ANTIOXIDANT CAPACITY OF THE GREEN LEAFY VEGETABLES USING OXYGEN RADICAL ANTIOXIDANT CAPACITY (ORAC), 2,2′-AZINO-BIS (3-ETHYLBENZOTHIAZOLINE-6-SULPHONIC ACID(ABTS) AND 2,2-DIPHENYL-1-PICRYLHYDRAZYL (DPPH) ASSAYS
Antioxidants are believed to play a very important role in the body defence system against reactive oxygen species (ROS), the harmful by-products that are generated during normal aerobic cell respiration. The objective o...
LEAF ANATOMY AND MICROMORPHOLOGY OF SELECTED PLANT SPECIES IN COASTAL AREA OF KUANTAN, PAHANG, MALAYSIA
Plant anatomy can play vital role in plant taxonomy for successfully resolve taxonomic problems among different plant species. The anatomical studies of plant species living in coastal area of Kuantan, Pahang are scarce....