CYTOTOXICITY STUDIES OF TETRAPRELYLTOLUQUINONE, A PRENILATED HYDROQUINONE FROM GARCINA COWA ROXB ON H-460, MCF-7 AND DU-145
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 3
Abstract
Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines.Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability.Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines.Conclusion: TPTQ had selective activity against H-460 cancer cell lines.Â
Authors and Affiliations
Fatma Sri Wahyuni, Johnson Stanslas, Nordin Hj Lajis, Dachriyanus Hamidi
Keywords
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