D-MELD does not predict post-liver transplantation survival: a single-center experience from Brazil
Journal Title: Annals of Hepatology - Year 2014, Vol 13, Issue 6
Abstract
Background. The D-MELD score was designed to prevent donor-recipient matches with a high risk of unfavorable outcome. The main objective of the present study was to assess the predictive value of the DMELD score for 1-month and 3-month post-transplant mortality in a cohort of patients who underwent deceased-donor liver transplantation in Southern Brazil. Material and methods. A cohort study was conducted. Receiver operating characteristic c-statistics were used to determine the ability of the D-MELD score to predict mortality. The Kaplan-Meier method was used to analyze survival as a function of time regarding D-MELD scores, and the Cox model was employed to assess the association between D-MELD and mortality. Results. Most recipients were male, with a mean age of 54.3 ± 9.6 years (n = 233 transplants). Mean donor age was 44.9 ± 16.8 years (19.3% of donors were aged ≥ 60 years). Mean MELD and D-MELD scores were 16.3 ± 7.1 and 733.1 ± 437.8 respectively. Overall survival at 1 and 3 months was 83.6%. The c-statistic value for 1- and 3-month mortality was < 0.5 for the D-MELD. Analysis of Kaplan-Meier curves for groups with D-MELD scores < 1,600 and ≥ 1,600 did not show statistically significant differences in survival (p = 0.722). Conclusion. D-MELD scores were unable to predict survival in this cohort of Brazilian liver transplant recipients.
Authors and Affiliations
Ane M. Costabeber, Lívia C. Lionço, Cláudio Marroni, Maria L. Zanotelli, Guido Cantisani, Ajácio Brandão
Keywords
Related Articles
- EP ID EP78454
- DOI -
- Views 120
- Downloads 0
Use of proteomic analysis tools to identify HCV-proteins down-regulated by acetylsalicylic acid
Background and aim. Acetylsalicylic acid (ASA) has been shown to downregulate HCV expression; however, the involved mechanisms are unknown. We used proteomic analysis to compare protein expression profiles between human...
The Optimal Transfusion Strategy in Liver Transplantation: The Quest Continues
-
Hepatitis C Virus Infection Outcomes Among Immigrants to Canada: A Retrospective Cohort Analysis
Introduction and aim. HCV-infected immigrants contribute to the total prevalence in Canada and other developed nations. Little is known about engagement in care, access to service, and treatment outcomes in recipients of...
Antioxidant effect of N-acetylcysteine on prehepatic portal hypertensive gastropathy in rats
Background. Portal hypertension is a clinical syndrome associated with the development of a hyperdynamic circulation and gastroesophageal varices. Aim. To evaluate the antioxidant effect of N-acetylcysteine on portal hyp...
Influence of ApoE and FABP2 polymorphisms and environmental factors in the susceptibility to gallstone disease
Background. Gallstone disease (GSD) is a common chronic disease in the Western hemisphere, yet environmental and genetic factors may be responsible for the variations in the prevalence of GSD among populations. Aim. To a...