Dapoxetine: An Innovative Approach in the Therapeutic Management in Animal Model of Depression
Journal Title: Pakistan Journal of Pharmaceutical Research - Year 2016, Vol 2, Issue 1
Abstract
Stress is a complicated condition that effects on person’s mental and physical health, and it is the precursor of other psychological disorders mainly depression. Serotonin (5-Hydroxytryptamine; 5-HT) is well known to have hypo function in unpredictable chronic mild stress whereas, unpredictable chronic mild stress (UCMS) has produced the most steady and continuous results of anhedonia and learned helplessness particularly in rats. The stress-induced depressive like behavior can be reversed by many antidepressants such as SSRIs. Selective serotonin [5-hydroxytryptamine (5-HT)] reuptake inhibitors (SSRIs) is mostly prescribed antidepressant that can deplete neurochemical and behavioral deficits. The present study was designed to investigate whether repeated administration of dapoxetine at dose (1.0 mg/kg) could reverse the behavioral deficits induced by UCMS in rat model of depression. UCMS induced behavioral deficits. Locomotive activity in familiar environment (home cage), novel (open field) environment and anxiolytic behavior in light/dark activity box were greater in unstressed group than stressed group. The inhibition of serotonin reuptake at pre-synaptic receptors by repeated dapoxetine administration is mainly the mechanism involved and discussed. This particular study may assist in novel approach for understanding the interaction between stress and behavioral functions and extending the therapeutic use of dapoxetine.
Authors and Affiliations
Muhammad Farhan
Keywords
Related Articles
- EP ID EP199914
- DOI 10.22200
- Views 114
- Downloads 0
Use of camel milk for reduction of Acetaminophen induced Hepatotoxicity: a review
The chemical composition of camel milk in various aspects is quite different from other animal milk and is abundant source of vitamins, minerals, most significantly vitamin B and vitamin C and iron. It is easily digested...
Biological activity of Terminalia arjuna on Human Pathogenic Microorganisms
World’s population relies chiefly on traditional medicinal plants, using their extracts or active constituents. Terminalia arjuna of family Combretaceae reported to be effective as aphrodisiac, expectorant, tonic, stypti...
Physicochemical characterization of medicinal essential oil made obtained from the rhizome of Zingiber officinale (ginger), grown in San Carlos, Costa Rica, in order to standardize future hydroponic
Introduction: Ginger is a medicinal plant native to India. Has been reported their potential use in cosmetics, medicines and natural products, however depending on crop conditions the medicinal components of the differen...
Comparison of Flurbiprofen Tablets Available In Pakistani Market and Their Absorption Studies
The aim of this present work was to compare different parameters of various brands of flurbiprofen tablets collected from different retail pharmacies in the local market of Pakistan. Four brands A, B, C and D were tested...
Antimicrobial and toxicity studies on Breynia disticha J.R.Forst. ForstG and Vernonia elaeagnifolia DC.
The present study was aimed to investigate the phytochemistry, toxicity and antimicrobial activity of the two plants Breynia disticha and Vernonia elaegnifolia. Tests for all the major secondary metabolites were carried...