DEPENDENCE OF YKL-40 mRNA TISSUE LEVELS ON KRAS MUTATION STATUS IN COLORECTAL CANCER - PRELIMINARY RESULTS
Journal Title: International Journal of Surgery and Medicine - Year 2015, Vol 1, Issue 2
Abstract
Colorectal cancer (CRC) is one of the most deadly cancers worldwide. Despite the introduction of targeted molecular therapies in the last 10 years, overall survival has not increased substantially. CRC progression is accompanied by numerous genetic and epigenetic alterations and dysregulation of several signaling pathways, among which activation of Wnt and inactivation of TGF-β signaling. The molecular heterogeneity of CRC, however, hinders the molecular subtyping of CRC and thus the identification of common biomarkers for this pathology. The only three well established biomarkers for advanced-colorectal-cancer drug treatment are negative biomarkers. These are mutations in the genes KRAS, NRAS and BRAF which determine resistance to therapy with anti-EGFR antibodies. YKL-40 is a chitin-binding glycoprotein that has been shown to play a role in extracellular tissue remodeling, angiogenesis, cell migration and inflammation. Increased serum levels of this protein have been detected in patients with CRC but the role of YKL-40 in this neoplastic disease has not been studied extensively and the precise function of YKL-40 in CRC progression is not known. In the present study we determined the KRAS mutation status and measured the mRNA levels of YKL-40 of 24 patients with sporadic CRC. In addition, we assessed the association between these two parameters by statistical analysis. We are the first to show that in CRC YKL-40 mRNA levels are dependent on the presence of KRAS mutations, being prominently elevated in the wild type background. Our results indicate the potential role of YKL-40 as a target molecule for CRC therapy.
Authors and Affiliations
Yana Feodorova, Dessislava Tashkova, Kiril Simitchiev, Anton Todorov, Gancho Kostov, Rossen Dimov, Victoria Sarafian
Keywords
Related Articles
- EP ID EP216532
- DOI 10.5455/ijsm.20150723012230
- Views 117
- Downloads 0
THE ROLE OF TRANSANAL ENDOSCOPIC MICROSURGERY IN THE TREATMENT OF T1N0 RECTAL CANCER – CASE SERIES AND REVIEW OF THE LITERATURE
Background: Currently, there has been an increasing trend toward transanal endoscopic microsurgery as a definitive treatment of T1 rectal cancer. Despite the promising results from the earlier series, the more recent stu...
CLINICAL EVALUATION OF EFFECT OF EARLY EXPOSURE OF WOUNDS AFTER MINOR SURGICAL PROCEDURES
Application of dressings to surgical wounds is a custom as old as history and has become a ritual marking the completion of surgery. Under certain circumstances a surgical dressing might in fact predispose to the develop...
IMPLEMENTING A QUALITY IMPROVEMENT FRAMEWORK FOR MAJOR AMPUTATION IN A SCOTTISH HEALTH BOARD (PATTERNS OF PERI-OPERATIVE MORTALITY AND AMPUTATION LEVEL)
We present a large contemporary series of patients presenting with unreconstructable critical limb ischaemia and requiring amputation. As well as being an insight into the challenges faced with the implementation of a qu...
INTERVENTION OR SURVEILLANCE? CURRENT EVIDENCE IN VISCERAL ARTERY ANEURYSMS
Visceral artery aneurysms (VAAs) are an increasingly encountered clinical problem. Although their incidence is low at about 0.2% in the general population, they are increasingly found on cross-sectional imaging. Therefor...
TREATMENT OF RENAL STONES WITH PERCUTANEOUS NEPHROLITHOTOMY IMPROVES RENAL FUNCTIONS IN CHRONIC KIDNEY DISEASE PATIENTS
In this study, we aimed to investigate the impact of percutaneous nephrolithotomy on kidney functions in stage III or higher chronic renal failure patients using glomerular filtration rate and serum creatinine level. Me...