Deposition Pattern of Polydisperse Dry Powders in Andersen Cascade Impactor - Aerodynamic Assessment for Inhalation Experimentally and In Silico
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2020, Vol 17, Issue 1
Abstract
Objectives: An impactor is a standard instrument that applied for particle deposition assessment in the pharmaceutical aerosols. It provides data comparison between inhaler formulations. However, the deposition pattern in the impactor is not clearly understood. In practice monodisperse aerosols were employed to calibrate the impactor. Materials and Methods: This study used polydisperse aerosols together with the computer simulation to track the particles in the impactor to understand the deposition pattern. Particles deposited on each stage of the Andersen cascade impactor were compared with its stage cut-off diameter using polydisperse aerosols by three particle sizing techniques. The relationship of cut-off diameter with particle size distribution was established for each stage. Also, the computational verification was used to complement the real experiments. Results: Projected diameters from microscope images showed that the size of particles varied on the stage’s collection plate, and the median size of each stage decreased along the lower stages from 8.53 to 0.92 μm. The median sizes measured by laser diffraction were close to the impactor’s cut-off diameters. In silico data showed that the outlet mass fractions gradually changed in size towards the lower stages. Conclusion: Polydisperse aerosols and in silico computer fluid dynamics may compliment to standard calibration method.
Authors and Affiliations
Janwit DECHRAKSA, Tan SUWANDECHA, Teerapol SRICHANA
Keywords
Related Articles
- EP ID EP684725
- DOI 10.4274/tjps.galenos.2018.15870
- Views 177
- Downloads 0
In Vitro Skin Permeation and Antifungal Activity of Naftifine Microemulsions
Objectives: Microemulsions are fluid, isotropic, colloidal systems that have been widely studied as drug delivery systems. The percutaneous transport of active agents can be enhanced by their microemulsion formulation wh...
Effects of Polyvinylpyrrolidone and Ethyl Cellulose in Polyurethane Electrospun Nanofibers on Morphology and Drug Release Characteristics
Objectives: Polyurethanes (PUs) are a popular choice for composing nanofibers due to their spinnability, biocompatibility, high chemical stability, and good mechanical and elasticity properties. The desired release behav...
Ferulic Acid Prevents Angiogenesis Through Cyclooxygenase-2 and Vascular Endothelial Growth Factor in the Chick Embryo Chorioallantoic Membrane Model
Objectives: This study was designed to verify the antiangiogenic activity of ferulic acid (FA) and its potency to inhibit cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) expression in the chorioall...
In Vitro Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profiles of Moltkia aurea and Moltkia coerulea
Objectives: In Turkey, the genus Moltkia Lehm. is represented by two species, namely Moltkia aurea Boiss. and M. coerulea (Willd.) Lehm., which are used as both food and for medicinal purposes. This study aimed to evalua...
Comparative In Vitro and In Vivo Evaluation of Fenofibric Acid as an Antihyperlipidemic Drug
Objectives: Fenofibric acid (FA) is antihyperlipidemic agent and commercially available as a tablet formulation that weighs 840 mg for 105 mg of active substance. A new formulation with less inactive substance was develo...