Depression: Review article
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 5
Abstract
To prove the post-natal depression model, the antidepressant sertraline, was assessed in rat mothers (n=14) divided into Prenatally Stressed (PS) and Non-Stressed (NS) groups. The data failed to support the hypothesis that ‘the progeny of 10mg of sertraline-treated PS mothers displayed less anxiety than the progeny of vehicle-treated PS mothers’. The forced swim test (FST) was used to examine depressive-like behaviour in mice. Barley successfully increased mobility in mice exposed to the FST. Barley was antidepressant at low doses (0.8g/kg and upwards) if used subchronic; and at high doses (6.4g/kg and 12.8g/kg) if used acutely; (n=113, 56 acute, 57 subchronic- treated). Barley (6.4g/kg) was also able to alleviate the depressive-behaviour in mice induced by the Reserpine Test (n=114, 58 reserpinised, 56 non-reserpinised) and Social ‘Defeat’ Test (n=24, 8 vehicle undefeated, 8 barley defeated, 8 vehicle defeated mice). To confirm that the anti-depressant effects of barley(6.4g/kg) were not simply due to increased locomotor activity in the FST, an Open Field Test(OFT) was undertaken (n=14,7 vehicle, 7 barley). Barley had no effect on locomotor activity and also caused no significant changes in weight (n=16; 8 vehicle, 8 barley). In mice, Barley (6.4 g/kg) significantly delayed the tremorogenic effects of Physostigmine (n=18, 6 control, 6 Physostigmine, 6 Physostigmine with barley); reduced bradykinesia induced by reserpine (n=18, 6 control, 6 vehicle, 6 barley treated); and was analgesic in nociception tests (n =20, 5 control, 5 barley, 5 pain, 5 pain with barley). Overall, barley was seen to have many useful properties, though its effect in PND remains to be assessed.
Authors and Affiliations
Mohammed Abdulrhman Alminggash, AbdulAziz AlHedethe, Abdullah Ali Alateeq, Majed Mohammed Alrobian
Keywords
Related Articles
- EP ID EP537175
- DOI 10.21276/ijmrp.2018.4.5.065
- Views 82
- Downloads 0
Retrospective Analysis of Road Traffic Accident Patients among Patients Visited in Tertiary Care Teaching Hospital
Background: Accidents, tragically, are not often due to ignorance, but are due to carelessness, thoughtlessness and over confidence. Materials & Methods: This study was conducted in the Department Community Medicine, Pac...
Seroprevalence of Japanese Encephalitis in Patients Attending Microbiology Department of MGM Medical College, Jamshedpur
Japanese Encephalitis is numerically one of the most important causes of viral encephalitis worldwide, with an estimated 50,000 cases and 15000 deaths annually. About one third of patients die and half of the survivors h...
Midgut Volvulus without Malrotation - A Rare Cause of Small Intestine Obstruction: A Case Report and Review of Literature
Midgut volvulus is one of the rare cause of intestinal obstruction in adults. A 35 year old female presented in emergency with complains of pain in lower and central abdomen for past 3 days. Patient has not passed flatus...
Orbital Infection as Rare Sequelae to the Extension of Odontogenic Infection: A Case Report and Review of Literature
Extension of dental abscess to distant areas of head & neck has been repeatedly reported in literature. Subsequent involvement of orbit is a rarity, though it may cause lasting damages resulting from insufficient therapy...
Computed Tomographic Evaluation in Spine Trauma with Neurological Correlation in Thoracolumbar Burst Fractures
Introduction: Radiology plays a crucial role in the evaluation of a traumatized patient by providing information that allows timely and appropriate management of the patient. Plain radiography still remains the foundatio...