Dermatological Manifestations of Gastrointestinal Tract Malignancies: A Rare Prospective Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Background: Dermatological manifestations of gastrointestinal tract (GIT) malignancies can be specific like cutaneous metastasis and nonspecific like paraneoplatic disorders and genodermatosis. They are protean but uncommon and usually appear during advanced stage of underlying malignancy. Sometimes they are presenting sign of an occult malignancy or represent recurrence of malignant process at first. The detection of this presentation is of utmost important for both clinician and patient. Objective: To determine the frequency of dermatological manifestations of GIT malignancies. Material and Methods: 140 patients of proven GIT malignancies were enrolled over a period of one year. Detailed history was taken, further head to toe examination of skin, hair, nails and mucosae were done. Procedures like skin biopsy, KOH examination, tzanck smear examination and imaging investigations were performed as per need to confirm our clinical diagnosis. Results: Out of 140 patients, 5(3.6%) patients developed rare paraneoplastic manifestations in the form of Bazex syndrome, PPP (Pancreatitis panniculitis polyarthritis) syndrome and acquired palmoplantar keratoderma. 3(2.1%) patients had metastasis to skin. One (0.7%) patient of Neurofibromatosis had adenocarcinoma of stomach. Other non-specific mucocutaneous manifestations were found in 71(50.7%) patients. Conclusion: It is emphasized that metastasis, genodermatosis and paraneoplastic dermatosis are very rare but detectable cutaneous manifestations of GIT malignancies. They may act as first sign to diagnose an asymptomatic underlying malignancy. Through high clinical suspicion and active diagnostic workup, a dermatologist/clinician can improve the patient’s prognosis by early detection and timely referral for treatment in such cases.
Authors and Affiliations
Dr Sandhya Chauhan
Keywords
Related Articles
- EP ID EP285180
- DOI -
- Views 54
- Downloads 0
Study of Sexual Dimorphism of Human Sternum in Indian Population
Aim: To study the sternum and its anatomical pattern and variation in population to show the sternum as one of the bone of sexual dimorphism. Material and Method: Two hundred and two adult human sternum of known age and...
Variation of Prolidase Activity: A Predictor of Neuropathy due to Diabetes Mellitus?
Prolidase is a member of the matrix metalloproteinase family responsible for collagen turnover which is implicated in the pathogenesis of diabetic neuropathy (DN). 50 (F-16, M-34) subjects suffering from T2DM, 46 subject...
Psychiatric Co-Morbidities in Patients Presenting with Headache: A Prospective Study
Background: Psychiatric disorders are commonly encountered in patients attending neurology OPD and headache is one of the most common complaints addressed by primary care physicians and neurologists. These psychiatric co...
A Prospective Study of Alteration in Liver Function Test after Laparoscopic Surgeries
Background: Laparoscopy is gaining wide popularity among surgeons in India. There have been no studies in our setting to evaluate the potential deleterious effects of laparoscopic surgery on hepatic function. This study...
Prevalence of Anemia and Its Causative Factors among Dental Undergraduate Students In A Dental College In South India
A healthy diet defines life in terms of sustainability and longevity. Nutrition forms an integral part of a healthy life style.1without a nourishing diet, it is impossible to perform for an individual. It not only affect...