Dermatological Manifestations of Gastrointestinal Tract Malignancies: A Rare Prospective Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Background: Dermatological manifestations of gastrointestinal tract (GIT) malignancies can be specific like cutaneous metastasis and nonspecific like paraneoplatic disorders and genodermatosis. They are protean but uncommon and usually appear during advanced stage of underlying malignancy. Sometimes they are presenting sign of an occult malignancy or represent recurrence of malignant process at first. The detection of this presentation is of utmost important for both clinician and patient. Objective: To determine the frequency of dermatological manifestations of GIT malignancies. Material and Methods: 140 patients of proven GIT malignancies were enrolled over a period of one year. Detailed history was taken, further head to toe examination of skin, hair, nails and mucosae were done. Procedures like skin biopsy, KOH examination, tzanck smear examination and imaging investigations were performed as per need to confirm our clinical diagnosis. Results: Out of 140 patients, 5(3.6%) patients developed rare paraneoplastic manifestations in the form of Bazex syndrome, PPP (Pancreatitis panniculitis polyarthritis) syndrome and acquired palmoplantar keratoderma. 3(2.1%) patients had metastasis to skin. One (0.7%) patient of Neurofibromatosis had adenocarcinoma of stomach. Other non-specific mucocutaneous manifestations were found in 71(50.7%) patients. Conclusion: It is emphasized that metastasis, genodermatosis and paraneoplastic dermatosis are very rare but detectable cutaneous manifestations of GIT malignancies. They may act as first sign to diagnose an asymptomatic underlying malignancy. Through high clinical suspicion and active diagnostic workup, a dermatologist/clinician can improve the patient’s prognosis by early detection and timely referral for treatment in such cases.
Authors and Affiliations
Dr Sandhya Chauhan
Keywords
Related Articles
- EP ID EP285180
- DOI -
- Views 76
- Downloads 0
A Study of Hypertension in Chronic Alcoholics
A chronic alcoholic is a person who is severely addicted to and dependent on alcohol. They will often have no job, no contact with family or friends, are not in control of their drinking, and may suffer from cognitive im...
EEG Pattern in Alzheimer’s Disease at Resting Condition
The aim of present Electroencephalography (EEG) study was to investigate the role of absolute power to discriminate Alzheimer’s disease patient and normal elderly subjects. EEG was recorded at rest in age-sex matched 30...
Metachronous Keratinising Squamous Cell Carcinoma of Skin After Adenocarcinoma of Descending Colon
Colorectal carcinoma is the most common malignancy of the GI tract, its development involving interplay between genetic and environmental influences. With advances in diagnostic techniques and treatment modalities, the n...
Diagnostic Utility of High Resolution Computed Radiography & Chest Radiography in Assessing Disease Activity in Chronic Lung Disease
HRCT uses high spatial resolution of lung parenchyma, using thin collimation, high-spatial frequency reconstruction algorithm, increased kVp and mA settings.. Alterations in anatomy can be identified at level of secondar...
Ephedrine Infusion Instead of Crystalloid Preloading to Prevent Spinal Hypotension in Lower Abdominal Surgeries
Spinal anesthesia is one of the most popular techniques for lower limb and lower abdominal procedures. Various prophylactic methods like prehydration, head up position and vasopressors have been used to minimize hypotens...