Design and Characterisation of a Polyethylene Oxide Matrix with the Potential Use as a Teat Insert for Prevention/Treatment of Bovine Mastitis
Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 1
Abstract
This manuscript reports (for the first time) on antibiotic-free polymeric inserts for the prevention and/or treatment of bovine mastitis. Polyethylene oxide (PEO)-based inserts were prepared using different concentrations of various hydrophilic polymers and water-soluble and water-insoluble drug-release-modifying excipients. A simple and scalable melt-extrusion method was employed to prepare the inserts. The prepared inserts were characterised for their dimension, rheological and mechanical properties. The in vitro release of a model bacteriostatic drug (salicylic acid) from the prepared inserts was studied to demonstrate the effectiveness and reproducibility of the melt-extrusion manufacturing method. Further, the in vitro stability of the inserts was evaluated using gel permeation chromatography (GPC) to monitor any change in molecular weight under real-time and accelerated storage conditions. The investigated inserts were stable at accelerated storage conditions over a period of 6 months. PEO inserts have the potential to serve a dual purpose, act as a physical barrier against pathogens invading the teat canal of cows and possibly control the release of a drug.
Authors and Affiliations
Sushila Bhattarai, Raid G. Alany, Craig R. Bunt, Hamdy Abdelkader, Michael J. Rathbone
Keywords
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