Design and development of chronomodulated pulsincap delivery system of deflazacort
Journal Title: Asian Pacific Journal of Health Sciences - Year 2018, Vol 5, Issue 4
Abstract
Aim of the present study was to formulate, evaluate and optimize the Pulsincap delivery system of deflazacort used in rheumatoid arthritis, based on the chronotherapeutic approach. The prepared pulsincap system consist of immediate release tablet sealed inside formaldehyde treated insoluble capsule body by hydrogel plug composed of polymer HPMC K15M and sodium alginate. Our target was to formulate a delivery system that could release the drug as per chronotherapeutic pattern of the disease (rheumatoid arthritis), so preliminary batches were prepared to study the effect of concentration of HPMC K15M and sodium alginate on the lag time of the drug release. Optimization of hydrogel plug was carried out by employing 32 full factorial design using Design expert 7 Software. The optimized batch of pulsincap sytem was found to release after a lag time of 366.66±2.887 minutes.
Authors and Affiliations
Binu Raina
Keywords
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- EP ID EP521211
- DOI 10.21276/apjhs.2018.5.4.32
- Views 215
- Downloads 0
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