Design and Development of Dual Drug Loaded Niosomes Containing Amoxicillin and Clavulanic acid
Journal Title: Asian Pacific Journal of Health Sciences - Year 2017, Vol 4, Issue 2
Abstract
Niosomes formulation for the fixed dose combinations of amoxicillin-clavulanic acid were prepared using Span 60 and cholesterol by the ether injection method. Span 60 and cholesterol were added in various molar ratios to affect the vesicle membrane rigidity. Drugs combinations of amoxicillin-clavulanic acid entrapped in the bilayer of niosomes were quantified and the entrapment efficiency was found to be reaching up to 76%. The size and size distribution of niosomes were determined on light microscopy and transmission electron microscopy. The accelerated stability testing was used to predict the stability of the formulations. The test revealed changes in the characteristics of the liposomes. The in-vitro antibacterial assay of amoxicillin-clavulanic acid, revealed that niosomes formulations have stronger inhibitory activity.
Authors and Affiliations
B Kumar
Keywords
Related Articles
- EP ID EP525837
- DOI 10.21276/apjhs.2017.4.2.33
- Views 206
- Downloads 0
Health challenges of adopted persons
Background: Adoption of persons has been a commonly practised by human for centuries. Despite its popularity, little attention has been given to the health challenges faced by adopted persons as a result of the adoption....
Rehabilitation of the traumatic anterior teeth with fiber post
The aim of this study is to benefit from fiber post restorative applications made with the support of the root canal in teeth that had suffered the loss of excess material. After the clinical and radiological evaluation...
Factors responsible for prolong waiting time of patients seeking eye care at a tertiary health facility
Prolong waiting time can cause poor utilization of health facility because it causes discontent among patients. The purpose of this study was to determine waiting time of patients attending the eye department of the ter...
A study on awareness of Dental students in Electronic Waste Management
Background: Electronic Waste or e-waste is one of the rapidly growing problems in the world. The old electronic appliances such as computers, laptops, TVs, DVD players and mobile phones etc which have disposed by their u...
Assessment of Premarital Haemoglobin Genotype Counselling in the Control of Haemoglobinopathies in Osogbo, Southwestern Nigeria
Introduction: Premarital haemoglobin genotype counselling is gradually becoming popular for joining a man and a woman together as husband and wife in Southwestern Nigeria but there are still many couples who marry withou...