DESIGN AND EVALUATION OF AN EXTENDED RELEASE TABLET DOSAGE FORM OF CLASS-II DRUG, QUETIAPINE FUMARATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The scenario of pharmaceutical drug delivery is rapidly changing, but conventional pharmaceutical dosage forms are still dominating. Of all dosage forms, tablets are the manufacturer’s dosage form of choice because of their relatively low cost of manufacture, package, and shipment; increased stability and virtual tamper resistance. The main objective of the work is to develop a pharmaceutical equivalent, stable, robust and extended release tablets of Quetiapine. Which is orally administered ,very well tolerated side effect , lower incidence of EPS, improved depressed mood, high patient acceptability and satisfaction in recent era. To achieve this goal, various prototype trials were taken and evaluate with respect to various quality parameters such as bulk density, sieve analysis, drug uniformity and dissolution.
Authors and Affiliations
Durga Pattanayak , Una Narayan , Alok Dash , Jhansee Mishra , Manoj Mishra
Keywords
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