DESIGN AND EVALUATION OF BUCCOADHESIVE CONTROLLED RELEASE FORMULATIONS OF PROCHLORPERAZINE MALEATE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 1
Abstract
Objective: The Purpose of this work was to design mucoadhesive tablets of prochlorperazine maleate to release the drug in buccal cavity for an extended period of time in order to avoid the first-pass metabolism.Methods: Six formulations were prepared using different polymer like Xanthan gum, Locust bean gum, Carbopol 974P NF, HPMC K100MCR, Polyox-WSR301 and Gantrez AN139 as a mucoadhesive and controlled release agents. The formulations were tested for content uniformity, thickness, weight variation, friability, in vitro drug release, in-vitro bio-adhesion, swelling index and residence time.Results: Drug excipient compatibility studies performed using DSC. The DSC studies revealed endothermic peak at 200o–205oC for Prochlorperazine maleate. Similarly endothermic peaks were obtained for separate excipient when heated in the range of 50-300 °C indicating their melting points. There was no separate peak observed when the drug was mixed with the different polymers like Xanthan gum, locust bean gum, Carbopol 974 P, HPMC K100 MCR, Gantrez AN139 and Polyox-WSR301 in ratio (1:1) indicating that no interaction took place between drug and polymers used in the study. Dissolution studies of the tablets of the optimized batch (BDS-6) containing Carbopol 974P (CP) and HPMC K100 MCR showed extended release 90.65% up to 24 hr. The bioadhesive force of optimized formulation is 12.18±.011 gm and the maximum swelling index was observed in 3.87±.0057 h.Conclusion: From the study it can be concluded that formulation BDS-6 containing Carbopol and HPMC K100 MCR give a promising result for sustained release action of PrM. Â
Authors and Affiliations
Sonia Pandey, Ritesh R. Shah, Arti Gupta, B. Arul
Keywords
Related Articles
- EP ID EP577972
- DOI -
- Views 90
- Downloads 0
THYMOL TEMPERS As (III) AND Hg (II) CAUSED HYPERCONTRACTILITY BY SIMILAR PATHWAYS IN ISOLATED AORTIC AND TRACHEAL RINGS
Objective: Thymol is known to cause smooth muscle relaxation, possibly by inhibition of Ca2+influx, release or loss of its sensitivity. It is, however, also reported to be a strong antioxidant in several other systems. I...
A PROSPECTIVE INTERVENTIONAL STUDY OF KNOWLEDGE, ATTITUDE AND PRACTICE (KAP) TOWARDS TUBERCULOSIS AMONG PATIENTS WITH KOCH’S DISEASE
ABSTRACTObjective: To evaluate the knowledge, attitude and practice (KAP) of tuberculosis patients and to provide structured patient education through patient counselling on disease, drugs and lifestyle modifications in...
G3XMP2 INVERSION STUDIES OF HETEROAROMATIC AMINES, N-ANILINE AND N, N-ANILINE DERIVATIVES
Objective: Nitrogen inversion in aniline and hetero aromatic amines are contrary in nature and hence inversion dynamics of the above two compounds are investigated by G3XMP2 theory to determine the configuration of the a...
ANTIMICROBIAL POTENTIALOF HEMOLYMPH AND HEPATOPANCREAS OFPORTUNUSSEGNISCRABS
Objective: The potential of marine crabs as a source of bioactive products is largely unexplored. Methods: Portunussegnis crabs were collected from the northern coast of Persian Gulf. Antimicrobial activities of hepatopa...
FOOD–DRUG INTERACTION AND THEIR CLINICAL IMPLICATIONS: SELECTED INVESTIGATIONS
Food-drug interactions occur as a result of pharmacokinetic or pharmacodynamics mechanisms. Pharmacokinetic mechanisms include what the body does to a drug while Pharmacodynamics mechanisms involve what drugs do to the b...