DESIGN AND EVALUATION OF CHRONOTHERAPEUTIC PULSATILE DRUG DELIVERY SYSTEM OF CILNIDIPINE
Journal Title: UNKNOWN - Year 2016, Vol 2, Issue 5
Abstract
At present scenario the drug regimen based on circadian rhythm is recently gaining much attention worldwide by researchers. Justification behind it is that, there are various diseases like asthma, hypertension, and arthritis show circadian variation that demand time scheduled drug release for effective drug action. A chronodelivery system, based on biological rhythms, is a state-of the- art technology for drug delivery. The aim of present work is formulate and evaluate a press coated pulsatile release tablets of Cilnidipine using an admixture of hydrophilic polymer i.e. hydroxypropyl methyl cellulose (HPMC) and pH sensitive polymers (ethyl cellulose, eudragit S-100) in order to achieve a predetermined lag time for chronopharmacotherapy of Hypertension. Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function used for the treatment of hypertension. The tablets prepared were evaluated for different properties like bulk density, tapped density, Angle of repose and Carr’s index), hardness, thickness, weight variation, friability, drug content uniformity and in vitro drug release study.
A REVIEW ON MEDICINAL USES OF DIFFERENT PLANTS OF EUPHORBIACEAE FAMILY
Euphorbiaceae is an important family which contains numerous medicinal plants. Most of the people in developing countries still today, relays on traditional medicine based largely on species of plants in human being and...
FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE
Terbinafine is a broad spectrum antifungal drug. The aim of present study was to develop topical nano emulgel of terbinafine using carbopol 934 as a gelling agent. The objective behind the formulation was to avoid dosing...
THE ROLE OF DIGITAL MARKETING IN MEDICAL TOURISM INDUSTRY IN POINT OF VIEW OF MEDICAL TOURISM POLICY MAKERS OF SHIRAZ IN 2017
Medical tourism refers to traveling to places where the individual could use medical services. Therefore, such a travel requires various activities in any of which the individual health is considered. Main samples of the...
ALHAGI MAURORUM AND TAMARIX APHYLLA -TWO MEDICINAL WEEDS MENTIONED IN HOLY QURAN AND AHADITH AND THEIR ETHNOMEDICINAL USES IN DISTRICT RAJHANPUR OF PAKISTAN
The present research work is based on two medicinal weeds: Alhagi maurorum and Tamarix aphylla (L.) mentioned in the 57 Ayat of Sura Al-Baqarah and 16 Ayat of Sura Saba in Holy Quran respectively. These plants were colle...
ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF BAPHIA NITIDA
Baphia nitida is a tropical plant used in African folkloric medicine for the treatment of infections and inflammatory conditions. This study therefore seeks to investigate the biological activities including antioxidant...