Design and evaluation of fast dissolving buccal films containing tadalafil
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2016, Vol 4, Issue 2
Abstract
The present research deals with formulation of a buccal film forming polymers based fast dissolving formulation of an erectile dysfunction drug, Tadalafil. This can offer higher patient compliance and excellent effectiveness of the drug. Low viscosity grade of hydroxypropyl methylcellulose (HPMC E 5 and HPMC E15) were used as excipient. Due to their excellent film forming property and palatable taste. PEG 400 and Propylene glycol were used as plasticizers. Tween 80 used as solubilizing agent, aspartame and menthol, pineapple flavor used as sweetener and taste masking agent respectively. Higher concentration of HPMC E 15 was resulted in sticky film formation. Concentration of PEG 400 and propylene glycol was optimized during preliminary studies. Formulation containing HPMC E 5 (150 mg), E 15 (100 mg) and PEG 400 and Propylene glycol (20 % w/w) showed optimum performance against all other prepared formulations. The formulation was found to show a significant improvement in terms of the drug release as compared to tablet formulation. Thus, fast dissolving buccal film formulation of Tadalafil was successfully developed.
Authors and Affiliations
Taddese Mekonnen
Keywords
Related Articles
- EP ID EP419775
- DOI -
- Views 53
- Downloads 0
To find the reference values of arch index in normal females (18 - 25) by footprint method- a survey-based study
Background Conventional shoes and sandals are built with features which reduce the workload of the foot’s intrinsic muscles, these features potentially interfere with the normal function and development of arch. If shoes...
A study to assess the effectiveness of planned teaching programme on needles tick injury among 2 year basic.b.sc nursing students in selected nursing college at vijyapur
Background Needle stick injury is so much common to the nursing students because they are unaware of its complications in future. The teaching programme may help the students to prevent the risk to get needle stick injur...
Primary malignant melanoma of the lower lip-A case report
Malignant melanoma is a malignant neoplasm composed of melanocytes or melanocytic precursors. Primary mucosal melanoma of the head and neck is a rare entity, in comparison than their cutaneous counterparts. The tumor occ...
Evaluation of antidiabetic activity on whole plant of Vanda Tessellate (Roxb) Hook
In the present study, an attempt was made to investigate phytochemical evaluation and in vivo Antidiabetic studies on the whole plant of vanda tessellate (Roxb) Hook.
Alternative control of blood pressure with tomatoes using the freeze drying method
Background Hipertension is one of the causes of maternal and fetal death. Handling hypertensive pregnant woman have been done with pharmacological drugs but can caused side effect. Tomatoes containing potassium and lycop...