Design and evaluation of lafutidine floating tablets for controlled release by using semi-synthetic and natural polymer
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 12
Abstract
Lafutidine is H2-receptor antagonist. The prepared tablets of various formulations were evaluated for a total floating time, buoyancy lag time, and percentage drug released. Guar gum is an efficient matrix forming agent in floating tablets by generating gas. Drug release from the prepared tablets was slowed over more 12 h and depended on the composition of guar gum and sodium bicarbonate. Lafutidine release was diffusion controlled and follows zero order kinetics. In case of F3 formulation non-fickian diffusion was the drug release mechanism from the prepared lafutidine floating tablets.
Authors and Affiliations
D. Lohithasu*| GITAM Institute of Pharmacy, GITAM University, Visakhapatnam- 530045, India., D. Midhun kumar| A.U. College of Pharmaceutical Sciences, Visakhapatnam- 530003, India., Hemasundara Rao. I| Sri Sai College of Pharmacy, Seetharampuram, Vizianagaram- 535005, India.
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