Abstract

Abstract The present research was carried out to develop mouth dissolving tablets using superdisintegrants and improve the solubility ultimately bioavailability of Telmisartan by encapsulating it inside the cavity of β-cyclodextrin. Mouth dissolving tablets improve the oral bioavailability by enhancing the drug disintegration and release of drug particles from the dosage form, which enable quick and direct delivery into the circulatory system by avoiding first pass metabolism. Total nine batches of mouth dissolving tablets were prepared using superdisintegrants like Crosscarmellose sodium (CCS), Sodium Starch Glycolate (SSG) and Crosspovidone (CP) by direct compression method. Precompression parameters (Angle of repose, Carr’s index and Hausner ratio) were in acceptable range as per the specifications given in IP. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability and the results were well within IP limits. Out of the nine formulations developed, the F7 – F9 formulations containing CP as super disintegrant had exhibited the gratifying results when compared with the other two. The results conclude that F9 is the best formulation containing 40 mg of CP. It showed the superlative results in terms of disintegration time, wetting time and In vitro drug release. F9 had low wetting time 8.22 sec, low in vitro disintegration time (5 sec), high water absorption ratio (180%) and highest drug release profile (99.81%) which releases the drug within 12 minute. The different kinetic models revealed that drug release followed zero order and diffusion mechanism. It was concluded from the results that prepared mouth dissolving tablets might decrease dosing frequency, enhance bioavailability, improves patient compliance, rapid onset of action and avoid first pass metabolism, which was the objective of the present work.

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