DESIGN AND EVALUATION OF MUCOADHESIVE BILAYER TABLETS OF SALBUTAMOL SULPHATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 5
Abstract
The salbutamol mucoadhesive tablets were prepared with objective of avoiding first pass metabolism and prolonging duration of action. Salbutamol mucoadhesive bi layered tablets were prepared by a direct compression method using bio adhesive polymers such as Carbopol-934, PVP and PVA along with ethyl cellulose as backing layer. The interaction between the excipcents and salbutamol was also studied through FTIR spectroscopy. Tablets were evaluated for their physical properties like hardness, friability and weight variation, uniformity of thickness, content uniformity and in vitro swelling study. In-vitro release studies of formulations were performed and data obtained from in-vitro release study were fitted to various kinetic models. The prepared formulations were passed the evaluation tests and the mechanism of drug release from tablets was found to be Quasi- Fickian Diffusion transport.
Authors and Affiliations
Arun Raj , Anjana Ashok, Josna P. B, Reshma Rajan
Keywords
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- EP ID EP126480
- DOI 10.7897/2230-8407.050576
- Views 108
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