DESIGN AND STATISTICAL OPTIMIZATION OF ANTACID ANALGESIC EFFERVESCENT TABLETS BY USING 2^3 FACTORIAL DESIGN
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: The present research work was undertaken with an aim to formulate a combination dosage form constituting an antacid and analgesic which may be useful in case of hyperacidity associated headache.Methods: In this formulation, a mixture of magnesium and aluminium hydroxide was used as the antacid. Ibuprofen was used as analgesic drug while, citric acid and tartaric acid along with sodium bicarbonate were used as effervescent mixture. The prepared tablets of all the formulations were evaluated for physical characterization.Results: The infra red spectra revealed that there was no chemical interaction between the drug and excipients which showed their compatibility. The results of these studies were found to be within the standard Pharmacopoeial limits. The release character was studied using the disintegration and dissolution studies conducted. The results of 23 factorial design revealed that the amounts of crosspovidone, tartaric acid and citric acid used in effervescent formulation significantly affected the dependent variables i. e. Hardness, friability and disintegration time etc. The stability studies of the tablet formulation showed that the tablets remained stable even after exposing to stress condition of temperatures.Conclusion: It was thus concluded that by adopting a systematic formulation approach, optimized release mechanism can be reached in the shortest time with minimum efforts.Â
Authors and Affiliations
Om Mahadeorao Bagade, Priyanka P. Kharat, Rohini R. Pujari, V. S. Raskar, Amruta M. Shete, Maduhri D. Vanve
Keywords
Related Articles
- EP ID EP579617
- DOI -
- Views 102
- Downloads 0
ANTIMYCOBACTERIAL ACTIVITY OF CRUDE EXTRACTS PRODUCED BY BACILLUS SP. ASSOCIATED WITH ENTOMOPATHOGENIC NEMATODE
Objective: The World Health Organization estimates that about 8 to 10 million new Tuberculosis (TB) cases occur annually worldwide and its incidence is currently increasing. There are two million deaths from TB each year...
VIRTUAL SCREENING OF PHYTOCHEMICALS FOR METHOTREXATE LIKE DIHYDROFOLATE REDUCTASE AND AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOTIDE (AICAR) TRANSFORMYLASE INHIBITORY PROPERTY USING MOLEGRO VIRTUAL DOCKER
Objective: Methotrexate is an effective treatment for autoimmune diseases like Rheumatoid arthritis, vasculitis, and Psoriasis. Our aim is to do in silico screening of various phytochemicals present in common medicinal p...
CHITOSAN NANOPARTICLES AS A NASAL DRUG DELIVERY FOR MEMANTINE HYDROCHLORIDE
Objective: The aim of the present study is to prepare crosslinked chitosan nanoparticles of memantine hydrochloride by using ionic gelation for nasal drug delivery system.Methods: The Memantine Hydrochloride loaded chito...
COMPARATIVE ANALYSIS OF THE IN VITRO ANTIOXIDANT ACTIVITY AND POLYPHENOLIC CONTENT OF SUCCESSIVE EXTRACTS OF NYCTANTHES ARBOR-TRISTIS LINN.
Objective: Present work comprehensively evaluates the antioxidant capacity, total phenolic content (TPC) and total flavonoid content (TFC) of four successive extracts of various parts of Nyctanthes arbor-tristis Linn. at...
GENOME-WIDE ANALYSIS OF LONG NON-CODING RNA (LNCRNA) OF AUTOIMMUNE THYROID DISEASES USING BIOINFORMATICS APPROACHES
Objective: Long non-coding RNA’s (lncRNA’s) have a crucial role in cancer biology. In this study, the genome sequence analysis of lncRNA expression in autoimmune thyroid disease is done to identify novel targets for...