DESIGN AND SYNTHESIS OF 7-CHLORO-3-SUBSTITUTED QUINAZOLIN-4(3H)-ONES AS POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC AGENTS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2017, Vol 9, Issue 5
Abstract
In our effort to identify potent anti-inflammatory and analgesic agents a number of 7-chloro-3-substituted-2-phenylquinazolin-4(3H)-ones have been synthesized starting from 4-chloro anthranilic acid. Docking analysis of the quinazolinone derivatives were done with COX-II protein which was carried out by means of the AutoDock program. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR, MS). The synthesized compounds were tested for their analgesic activity by tail-flick method and anti-inflammatory activity by carrageenan induced rat paw oedema method. Preliminary evaluation of the anti-inflammatory and analgesic properties of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to diclofenac standard.
Authors and Affiliations
Arun Mahato, Birendra Shrivastava, Nithya Shanthi
Keywords
Related Articles
- EP ID EP618317
- DOI 10.25004/IJPSDR.2017.090513
- Views 74
- Downloads 0
ACUTE TOXICITY, IN-VITRO UROLITHIATIC & DIURETIC EVALUATION OF METHANOLIC EXTRACT OF HYGROPHILA SALICIFOLIA, WHOLE HERB IN RAT
Hygrophila salicifolia (Family: Acanthaceae) is an erect herb, nearly glabrous, mainly whole herb used as raw material in medicine. The aim of present investigation was to evaluate acute toxicity, in vitro urolithiatic a...
HEPATOPROTECTIVE POTENTIAL OF HYDROALCOHOLIC EXTRACT OF SANTALUM ALBUM LINN. LEAVES
The present study was designed to evaluate the hepatoprotective activity of leaves of Santalum album in experimentally induced liver injury by carbon tetrachloride and paracetamol. The levels of serum marker enzymes, bil...
3D QSAR ANALYSIS ON OXADIAZOLE DERIVATIVES AS ANTICANCER AGENTS
Three dimensional quantitative structure activity relationship (3D QSAR) study by means of partial least square regression (PLSR) method was performed on a series of 3-(Aryl)-N-(Aryl)-1, 2, 4-Oxadiazol-5-amines as antipr...
ANTI-INFLAMMATORY EFFECTS AND SAFETY OF EXTRACTS AND ESSENTIAL OIL FROM CLINOPODIUM GILLIESII (MUÑA MUÑA)
The chemical machinery of vegetables offers a great diversity of biological properties and plays a fundamental role in the field of pharmacology. The search for new drugs with fewer adverse effects represents a challenge...
IMMUNOMODULATORY EFFECTS OF TINOSPORA CORDIFOLIA LOTION ON INTERLEUKIN-1, INTERLEUKIN-6 AND INTERLEUKIN-8 LEVELS IN SCABIES-INFECTED PEDIATRIC PATIENTS: A SINGLE BLIND, RANDOMIZED TRIAL
Scabies is a contagious, parasitic skin infestation caused by Sarcoptes scabiei mite, which has the ability to regulate the host’s inflammatory and immune responses. It is a serious community health problem in many less-...