DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION
Journal Title: Вісник Одеського національного університету. Хімія - Year 2015, Vol 20, Issue 4
Abstract
Coordination compounds of essential microelement germanium(IV) with metals (Mg, Na, K, Ca, Cu, etc.) and organic ligands – biocatalysts, antidotes at intoxications and regulators of mineral metabolism in living organism (nicotinic, citric, tartaric, 1-hydroxyethylidendiphosphonic acids, nicotinamide) are synthesized for the first time on the Department of General Chemistry and Polymers of Odessa Mechnikov National University. The favorable activity of the synthesized compounds on cardiovascular and chronic respiratory diseases, senile pneumonia, neuropsychiatric and metabolic disorders, ischemic heart diseases, etc. is described. Thus, the influence of 1-hydroxyethylidendiphosphonatogermanate (medgerm) on CNS, its anxiolytic activity and absence of both hypnotic and myorelaxant effects has been shown. Cardioprotector properties of magnesium hydroxyethylidendiphosphonategermanate as a potential effective and safe drug with the high antihypertensive and antiarrhythmic activity have been found out. The interferoninductive and immunostimulatory activity of germanium(IV) compounds with 1-hydroxyethylidendiphosphonic, nicotinic acids, nicotinamide, pyracetam has been studied. Injection of these drugs (concentration 100-125 μg/ml) causes the 100 % delay of cytopathic action of vesicular stomatitis virus in the cell cultures that demonstrates the ability of compounds to increase essentially cells stability. The perspectives of germanium coordination compounds as interferon inductors and as immune pharmaceuticals for prevention the disbalance of the immune system are reviewed.
Authors and Affiliations
I. I. Seifullina, E. E. Martsinko, E. V. Afanasenko
Keywords
Related Articles
- EP ID EP408949
- DOI 10.18524/2304-0947.2015.4(56).56690
- Views 63
- Downloads 0
CRYSTAL STRUCTURE OF THE COMPOUNDS Er2.34Се(Pr)0.66Ge1.28S7
Quaternary compounds Er2.34Се(Pr)0.66Ge1.28S7 are formed in the quasi-ternary systems Er2S3–R2S3–GeS2 (R–Ce, Pr) at 770 K. The structure of these compounds was determined from data sets obtained from homogeneous samples...
MODIFICATION OF THE ORGANO-POLYMERIC ANIONITES SURFACE WITH XYLENOL ORANGE BY SORPTION
In this paper, the peculiarities of xylenol orange sorption removal with the help of organopolymeric anion exchangers AB-17-8 and Granion AWA-G1 in the static mode are studied. The state of the matrix and the surface of...
ANTIOXIDANTS IN FOOD PRODUCTS AND METHODS OF THEIR DETERMINATION
The content of antioxidants of phenolic type in different types of vegetable raw materials and foodstuff and their influence on a human body is considered. It is shown that for determination of antioxidants chromatograph...
STOICHIOMETRY AND STRUCTURE OF TETRAFLUOROBORATE COMPLEXES OF Zn(II) WITH ISOMERIC PHENYLENDIAMINES
The tetrafluoroborate complexes of Zn (II) with o-, m- and p-phenylenediamines (FDA) have been synthesized. The investigation of the stoichiometry and the structure of synthesized compounds have been carried out by diffe...
PRODUCTS OF COMPLEXATION OF SnCl4 WITH SALICYLOYL-( β-, γ-PYRIDINOYL)HYDRAZONES OF 2- AND 4-METHOXYALDEHYDES, THEIR ANTIMICROBIAL ACTIVITY
Complexes of different types: molecular chelates [SnCl4(HL1,2)]∙nCH3CN (I, II) and zwitterionic [SnCl4(L∙H3-6)] ∙ nCH3CN (III-VI) – were synthesized by interaction of SnCl4 with salicyloyl-(HL1,2), β-,γ- pyridinoyl)hydra...