Design and synthesis of two steroid derivatives from 2-nitroestrone and theoretical evaluation of their interaction with BRCA-1
Journal Title: Asian Journal of Green Chemistry - Year 2019, Vol 3, Issue 2
Abstract
Several compounds have been prepared to treatment of breast cancer; however, some of these drugs may produce some side effects. The aim of this study is to synthesize two new steroid derivatives (Compounds 7 or 8) to evaluate their theoretical interaction with a breast cancer protein (BRCA-1) using a docking model. The preparation of 7 and 8 was carried out using a series of reactions which involves; (i) addition/cyclization; (ii) amination, (iii) etherification and (iv) esterification. Chemical structure of the compounds was confirmed using elemental analysis and NMR spectrum. The following stage involved the theoretical evaluation on the interaction of both compounds 7 or 8 with BRCA-1 protein surface using a docking model. The results showed that compound 7 could bound to different type of amino acid residues of BRCA-1 protein compared with 8; this phenomenon, may exert changes in the biological activity of BRCA-1 protein. All data suggest that compound 7 or 8 could be an alternative therapeutic for treatment of the breast cancer.
Authors and Affiliations
Figueroa-Valverde Lauro, Diaz-Cedillo Francisco, Rosas-Nexticapa Marcela, Mateu-Armand Virginia, Montano-Tapia Elizabeth, Hau-Heredia Lenin, Lopez-Ramos Maria, García-Cervera Elodia, Pool-Gómez Eduardo, Cauich-Carrillo Regina, Alfonso-Jimenez Alondra, Cabrera-Tuz Jhaira
Keywords
Related Articles
- EP ID EP468914
- DOI 10.22034/ajgc.2018.144189.1093
- Views 94
- Downloads 0
Imidazole mediated synthesis of spirooxindoles in water using isatin as a privileged scaffold
This work describes the synthesis of complex small molecules spirooxindoles using imidazole as an efficient organocatalyst. The three components coupling reactions of isatin, malononitrile and enolizable 4-hydroxycoumari...
Tribromo melamine (TBM) as an efficient and inexpensive catalyst for the one-pot synthesis of benzimidazoles and benzoxazole derivatives
In this work, a simple and facile method for the preparation of tribromo melamine (TBM or melamine‐Br3) as an environmentally friendly homogeneous catalyst is described as it is used for the one-pot synthesis of benzimid...
Identification of lectins from the seeds of Bangladeshi plants Sesbania bispinosa and Senna occidentalis by hemagglutination assay
The hemagglutination assay is a simple and easy method to specify a lectin. An activelectinagglutinates erythrocytes by recognizing a carbohydrate on the cell surface and forming a cross-linked network in suspension. The...
Indole derived “turn-on” fluorometric probe for dual detection of Hg2+ and Cu2+ ions at nanomolar level
The newly synthesized 3-(phenyl(phenylthio)methyl)-1H-indole ligand demonstrates chemosensor activity towards environmental and clinically important metal ions viz. Hg2+ and Cu2+, via fluorescence intensity enhancement....
One-pot, clean and energy efficient synthesis of dibenzo[b,f][1,4]oxazepine derivatives promoted by ultrasound
In the present study, a variety of dibenzo [b,f][1,4] oxazepine derivatives was successfully synthesized in good yields under ultrasonic irradiation as an environmental friendly technique. This one-pot method is practica...