DESIGN, DEVELOPMENT, AND EVALUATION OF AN ION-ACTIVATED OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROCHLORIDE

Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 3

Abstract

Objective: The objective of this study was to develop an in situ ophthalmic gel of an anti-infective drug, moxifloxacin (MOX) hydrochloride (HCL), for sustained ocular delivery for the treatment of bacterial infections of the eye. Method: In the present work the in situ gelling systems were prepared by ion exchange method with the help of various concentrations of gelling agent gelrite (0.08 g, 0.1 g and 0.12 g) and sodium alginate (0.6 g, 0.8 g and 1 g) as viscosity enhancer were added in the formulation; 9 formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for the analysis of variance using Design-Expert version 10 software. Statistical models were generated for each response parameter. Results: Optimized formulation batch F7 (0.12% gelrite and 0.6% sodium alginate) was liquid before addition of simulated tear fluid (STF) and underwent rapid gelation on addition of STF and had given 84.05% cumulative drug release; the formulation was found to be clear, having good in situ gelling capacity, good antibacterial efficacy, having drug content 99.75%; optimized formulation was sterile and showed sustained drug release over 8 h period as compared to marketed eye drop. Conclusions: From the above results, we can concluded that 32 full factorial design and statistical models can be successfully used to optimize the formulations, and it was concluded that the trial batch F7 (0.12% gelrite and 0.6% sodium alginate) is the best formula (percentage cumulative drug release over 84.05%) and it is possible to formulate in situ ophthalmic gels of MOX HCL using gelrite in combination with sodium alginate for the treatment of various bacterial infections of the eyes.

Authors and Affiliations

GIRISH KONDALKAR, ASISH DEV

Keywords

Related Articles

FACTORS CONTRIBUTING TO NON-ADHERENCE TO MEDICATIONAMONG TYPE 2 DIABETES MELLITUS IN PATIENTS ATTENDING TERTIARY CARE HOSPITAL IN SOUTH INDIA

 Objective: The aim was to determine the non-adherence to medication and to assess the factors affecting the same among the Type 2 diabetesmellitus (DM) patients in a tertiary care hospital in South India.Methods: A cro...

PHYTOCHEMICAL SCREENING AND ANTIDIABETIC ACTIVITY OF DIFFERENT LEAF EXTRACTS FROM LOTUS (NELUMBO NUCIFERA GAERTN.) IN STREPTOZOTOCIN INDUCED MICE

  Objective: The present study is to evaluate the antidiabetic activity of various extract of Lotus (Nelumbo nucifera Gaertn.) leaf using hexane, ethyl acetate, and ethanol organic solvent.Methods: Standard phytochemic...

Hexavalent Chromium Induced Alteration of Carbohydrate Bioenergetics: A Dose-dependent Study

Objective: This study was conducted to observe the dose-dependent effect of Cr (VI) on certain aspects of carbohydrate metabolism in mice with four different doses, viz., 5 mg/kg, 10 mg/kg, 15 mg/kg and 20 mg/kg b.w., re...

FALSE DIAGNOSIS IS A THREAT - A CASE STUDY

Objective: To explore the possibility of false diagnosis and threat to health. Methods: In  the  present  study,  a  case  history  of  23-year–old  lactating  woman&nbs...

TRIMETHOPRIM DETERMINATION WITH DRUG-SELECTIVE ELECTRODES

Developed ion-selective electrode has been industrialized for the determination of trimethoprim (TMP) in pure form and pharmaceutical preparations. The selective electrode was made from TMP with pairing agent methyl oran...

Download PDF file
  • EP ID EP603833
  • DOI -
  • Views 154
  • Downloads 0

How To Cite

GIRISH KONDALKAR, ASISH DEV (2019). DESIGN, DEVELOPMENT, AND EVALUATION OF AN ION-ACTIVATED OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROCHLORIDE. Asian Journal of Pharamceutical and Clinical Research, 12(3), 94-103. https://europub.co.uk/articles/-A-603833