DESIGN DEVELOPMENT AND EVALUATION OF BUCCAL TABLET CONTAINING NICORANDIL AS A MODEL DRUG
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Objective: Nicorandil is a vasodilatory drug used to treat angina. Nicorandil has oral bioavailability (70%) and half-life 1 hr. It is administered throughthe buccal mucosa enters directly in the systemic circulation, thereby minimizing the first pass hepatic metabolism and adverse gastro-intestinaleffects. Therefore, the present investigation is concerned with the development of the buccal tablets.Methods: The present work was performed to develop and evaluate buccal tablet containing anti-diabetic drug (nicorandil). Ethyl cellulose was usedas backing membrane and carbopol 934p and hydroxypropyl methyl cellulose K100M was used as bucco adhesive polymer. Aspartame was used as asweetener. Thickness, hardness, weight variation and drug uniformity were investigated.Results: The tablet formulations were also subjected to drug release in 250 ml 6.8 phosphate buffer. Ex vivo bioadhesion, retention time andpermeation through porcine buccal mucosa membrane. F5 formulations showed maximum amounts of drugs release (89.24%) at the end of 10 hrsdissolution study. F5 also showed maximum bioadhesion (0.0791 N) and the resident time of F5 formulation was 9.5 hrs. It shows 49.32% drugrelease after 10 hrs permeation study through porcine buccal mucosa mounted in Franz cell.Conclusion: The results of the study suggested that new buccal tablet formulations of combined bucco adhesive polymers can be suitably developedas an alternate to conventional dosage forms.Keywords: Nicorandil, Buccal tablet, Ex vivo bioadhesion, Ex vivo permeation.
Authors and Affiliations
Hardik Parmar, Biswajit Biswal, Jyotiranjan Nayak
Keywords
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