DESIGN, FORMULATION AND CHARACTERIZATION OF TENOFOVIR MICROEMULSION AS ORAL DRUG DELIVERY
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 1
Abstract
The aim of the present research was to design, formulate and evaluate Tenofovir Microemulsion. Tenofovir, a Nucleotide Reverse transcriptase inhibitor belongs to the category of anti retro viral drug. The oral bioavailability of Tenofovir is 25% due to its poor water solubility. An attempt was made to enhance solubility by formulating oral Microemulsion of Tenofovir. The solubility of Tenofovir in various Oils, Surfactants and Cosurfactants were checked to optimize the components of Microemulsion. Pseudo ternary diagrams were constructed to identify the area of Microemulsion region. A Microemulsion system with oleic acid as Oil phase, Tween 20 as surfactant and Ethanol as Cosurfactant was developed for oral delivery of Tenofovir. To achieve the objective of present study, Microemulsion formulations were prepared by using different ratios of Oil, Surfactant: Cosurfactant and Water. The prepared formulations of Tenofovir were characterized for thermo dynamic stability studies, pH, transparency, viscosity, drug content and in vitro drug release. Particle size and Zeta potential of optimized formulation were found to be 54.30nm and -5.61mV. Among four formulations, TME4 shows highest drug release of 86.88%. The invitro release was found to follow Non-fickian diffusion mechanism. These results demonstrate the potential use of Microemulsion for improving the Bioavailability of poor water soluble compound Tenofovir.
Authors and Affiliations
Divya A*, , CH. Praveen Kumar , K. Gnanaprakash , M. Gobinath
Keywords
Related Articles
- EP ID EP95679
- DOI -
- Views 184
- Downloads 0
SCREENING OF PHYTOCHEMICAL CONSTITUENTS FROM CERTAIN FLOWER EXTRACTS
Extracts were prepared by adding 50 g of fresh flowers of Dillenia pentagyna Roxb., Garcinia gummigutta L., Hamelia patens Jacq., Hyptis suaveolens (L.) Poit., Ipomea tricolor Cav., Ixora coccinea L., Ochna obtusata DC.,...
THERAPEUTIC PROPERTIES OF MEDICINAL PLANTS: A REVIEW OF THEIR DERMATOLOGICAL EFFECTS (PART 1)
Previous studies showed that medicinal plants exerted a wide range of dermatological effects. These plants included: Adiantum capillus-veneris, Agrimonia eupatoria, Allium sativum, Aloe vera, Ammannia baccifera, Ammi maj...
A RIEVEW OF COMPARATIVE STUDY OF RICE BRAN OIL AND RICE BRAN WAX
Rice bran wax is a natural vegetable wax and is a value added by product of Rice bran oil refineries. According to the Indian Council of Medical Research. Rice bran oil has an almost balanced fatty acid composition that...
CHEMICAL PENETRATION ECHEMICAL PENETRATION ENHANCERS: FOR TRANSDERMAL DRUG DELIVERY SYSTEMSNHANCERS: FOR TRANSDERMAL DRUG DELIVERY SYSTEMS
The evolutionary development of the human skin as a protective potential barrier which keep noxious substances out of the body, also maintaining the body temperature and prevent excessive loss of water from the internal...
PHYTOCHEMICAL AND PHARMACOGNOSTICAL EVALUATION OF PALASH PANCHANG (BUTEA MONOSPERMA LAM. KUNTZ.)
The present work deals with the pharmacognostical and prelimnary phytochemical study of Palash (Butea monosperma Lam. Kuntz.) panchanga (Rootbark, stembark, leaf, flower and seed). The purpose of this study is to determi...