DESIGN, FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASE TABLET FORMULATIONS OF LEVOSULPIRIDE
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 3
Abstract
Levosulpiride is a widely used gastroprokinetic agent in the treatment of various gastric disorders. It’s short half-life and increased dosage frequency leads to poor compliance and possible adverse effects. The prime objective of the current study was to develop a sustained release formulation of Levosulpiride by Direct compression method using polymers like Carboxymethyl cellulose sodium (CMC), Hydroxypropyl cellulose (HPC) and Hydroxypropylmethyl cellulose (HPMC) in varying concentrations. The prepared tablets were then evaluated for various physical parameters. The in-vitro absorbance was determined at a wavelength of 214nm using UV/Visible spectrophotometer and the data was analyzed using different kinetic models. The release profile was best expressed by Higuchi model as the results shows high linearity. The results also proved CMC sodium to be the best retarding material than HPC and HPMC, hence concluded that sustained release matrices of Levosulpiride can be prepared using CMC Sodium, HPC and HPMC as carriers.
Authors and Affiliations
Dr. Muhammad Samie
Keywords
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